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YAP1 binds TEAD3
Stable Identifier
R-HSA-8871266
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
YAP1 binds TEAD3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
YAP1 is a transcriptional coactivator that can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19324876
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
Lim, CJ
,
Hong, W
,
Loo, LS
,
Huang, C
,
Chan, SW
,
Chong, YF
J Biol Chem
2009
Participants
Input
TEAD3 [nucleoplasm]
(Homo sapiens)
YAP1 [nucleoplasm]
(Homo sapiens)
Output
TEAD3:YAP1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Orthologous Events
YAP1 binds TEAD3 (Bos taurus)
YAP1 binds TEAD3 (Caenorhabditis elegans)
YAP1 binds TEAD3 (Canis familiaris)
YAP1 binds TEAD3 (Gallus gallus)
YAP1 binds TEAD3 (Mus musculus)
YAP1 binds TEAD3 (Rattus norvegicus)
YAP1 binds TEAD3 (Sus scrofa)
Authored
D'Eustachio, P (2012-02-03)
Reviewed
Sudol, M (2012-02-03)
Created
Jupe, S (2016-05-13)
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