CDK5:p25 phosphorylates FOXO3

Stable Identifier
R-HSA-8870558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CDK5:p25 phosphorylates FOXO3
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CDK5, aberrantly activated by binding to p25, phosphorylates transcription factor FOXO3 on serine residues S43, S173, S294 and S325 (Shi et al. 2016).

Literature References
PubMed ID Title Journal Year
26962010 Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Viccaro, K, Shi, C, Lee, HG, Shah, K

J. Cell. Sci. 2016
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of CDK5:p25 [cytosol]

Physical Entity
CDK5:p25 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Cdk5:p25 phosphorylates FOXO3 (Homo sapiens)
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-05-11)
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