CDK5:p25 phosphorylates FOXO3

Stable Identifier
R-HSA-8870558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDK5, aberrantly activated by binding to p25, phosphorylates transcription factor FOXO3 on serine residues S43, S173, S294 and S325 (Shi et al. 2016).

Literature References
PubMed ID Title Journal Year
26962010 Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Shi, C, Viccaro, K, Lee, HG, Shah, K

J. Cell. Sci. 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [cytosol]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Created