SLC36A4 transports L-Trp from extracellular region to cytosol

Stable Identifier
R-HSA-8870352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
Synonyms
L-tryptophan(in) = L-tryptophan(out)
ReviewStatus
5/5
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SLC36A4 transports L-Trp from extracellular region to cytosol
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Plasma membrane-associated SLC36A4 (solute carrier family 36 member 4, also known as PAT4 - Proton-coupled amino acid transporter 4) mediates the uptake of extracellular L-Trp (L-tryptophan) (Pillai & Meredith 2011).
Literature References
PubMed ID Title Journal Year
21097500 SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes

Pillai, SM, Meredith, D

J. Biol. Chem. 2011
Participants
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Output
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as an event of
Event Information
Go Biological Process
L-tryptophan transmembrane transport (1904556)
Catalyst Activity

L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane]

Physical Entity
SLC36A4 [plasma membrane] (Homo sapiens)
Activity
L-tryptophan transmembrane transporter activity (GO:0015196)
Orthologous Events
SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)
SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)
SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)
SLC36A4 transports L-Trp from extracellular region to cytosol (Dictyostelium discoideum)
SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)
SLC36A4 transports L-Trp from extracellular region to cytosol (Gallus gallus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)
SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2016-05-09)
Reviewed
Jassal, B  (2016-12-23)
Created
D'Eustachio, P  (2016-05-09)
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