SLC36A4 transports L-Trp from extracellular region to cytosol

Stable Identifier
R-HSA-8870352
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC36A4 transports L-Trp from extracellular region to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plasma membrane-associated SLC36A4 (solute carrier family 36 member 4, also known as PAT4 - Proton-coupled amino acid transporter 4) mediates the uptake of extracellular L-Trp (L-tryptophan) (Pillai & Meredith 2011).

Literature References
PubMed ID Title Journal Year
21097500 SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes

Pillai, SM, Meredith, D

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
L-tryptophan transmembrane transport (1904556)
Catalyst Activity

L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane]

Physical Entity
SLC36A4 [plasma membrane] (Homo sapiens)
Activity
L-tryptophan transmembrane transporter activity (GO:0015196)
Orthologous Events
SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)
SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)
SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)
SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)
SLC36A4 transports L-Trp from extracellular region to cytosol (Gallus gallus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)
SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)
SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)
Authored
D'Eustachio, P  (2016-05-09)
Reviewed
Jassal, B  (2016-12-23)
Created
D'Eustachio, P  (2016-05-09)
Cite Us!