The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

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R-HSA-8869560
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Reaction [omitted]
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Homo sapiens
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In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the NOP2 (p120) gene, represses transcription of the nucleolar protein NOP2. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the NOP2 gene promoter (Liu et al. 2007). NOP2 is a proliferation marker (Valdez et al. 1992).

Literature References
PubMed ID Title Journal Year
17318229 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation

Liu, H, Tan, BC, Tseng, KH, Chuang, CP, Yeh, CW, Chen, KD, Lee, SC, Yung, BY

EMBO Rep. 2007
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