Reactome | HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

Stable Identifier

R-HSA-8869558

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, mitochondrial matrix

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HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

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In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the HSPD1 (Hsp60) gene, represses transcription of the mitochondrial matrix chaperonin HSPD1. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the HSPD1 gene promoter (Liu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17318229	Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation Liu, H, Tan, BC, Tseng, KH, Chuang, CP, Yeh, CW, Chen, KD, Lee, SC, Yung, BY	EMBO Rep.	2007