HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

Stable Identifier
R-HSA-8869558
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
5/5
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HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer
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In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the HSPD1 (Hsp60) gene, represses transcription of the mitochondrial matrix chaperonin HSPD1. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the HSPD1 gene promoter (Liu et al. 2007).
Literature References
PubMed ID Title Journal Year
17318229 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation

Yung, BY, Chuang, CP, Chen, KD, Tseng, KH, Tan, BC, Yeh, CW, Liu, H, Lee, SC

EMBO Rep. 2007
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
NPM1:TFAP2A homodimer:HSPD1 gene [nucleoplasm] (Homo sapiens)
Active Unit
NPM1:TFAP2A homodimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Dawid, IB  (2016-05-04)
Created
Orlic-Milacic, M  (2016-05-05)
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