Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter
Stable Identifier
R-HSA-8869549
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (Homo sapiens)
TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In response to retinoic acid treatment, TFAP2A (AP-2 alpha) homodimers in complex with NPM1 (nucleophosmin) are recruited to the AP-2 alpha response element in the promoter of the transcription factor MYBL2 (b-Myb) (Liu et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17318229
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
Yung, BY
,
Chuang, CP
,
Chen, KD
,
Tseng, KH
,
Tan, BC
,
Yeh, CW
,
Liu, H
,
Lee, SC
EMBO Rep.
2007
Participants
Input
MYBL2 gene [nucleoplasm]
(Homo sapiens)
NPM1:TFAP2A homodimer [nucleoplasm]
(Homo sapiens)
Output
NPM1:TFAP2A homodimer:MYBL2 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (Homo sapiens)
Authored
Orlic-Milacic, M (2016-03-14)
Reviewed
Zarelli, VE (2016-05-04)
Dawid, IB (2016-05-04)
Created
Orlic-Milacic, M (2016-05-05)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text