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Dissociation of clathrin-associated proteins
Stable Identifier
R-HSA-8869438
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After the removal of the clathrin coat, it is likely that many of the proteins that contributed to vesicle formation are lost, although the timing and mechanism of this step are poorly understood (reviewed in McMahon and Boucrot, 2011; Lemmon, 2001).
Literature References
PubMed ID
Title
Journal
Year
21779028
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
Boucrot, E
,
McMahon, HT
Nat. Rev. Mol. Cell Biol.
2011
11231140
Clathrin uncoating: Auxilin comes to life
Lemmon, SK
Curr. Biol.
2001
Participants
Input
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane]
(Homo sapiens)
Output
AMPH:BIN1 [cytosol]
(Homo sapiens)
AP-2 Complex [cytosol]
(Homo sapiens)
ARP2/3 complex [cytosol]
(Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane]
(Homo sapiens)
DNM:GDP [cytosol]
(Homo sapiens)
EPS15 [cytosol]
(Homo sapiens)
f-actin [plasma membrane]
(Homo sapiens)
FNBP1 dimer [cytosol]
(Homo sapiens)
FNBP1L dimer [cytosol]
(Homo sapiens)
GAK,DNAJC6 [cytosol]
(Homo sapiens)
GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane]
(Homo sapiens)
HIP1 dimer [cytosol]
(Homo sapiens)
HIP1R dimer [cytosol]
(Homo sapiens)
ITSNs [cytosol]
(Homo sapiens)
NECAPs [cytosol]
(Homo sapiens)
PACSIN dimers [cytosol]
(Homo sapiens)
PI4P [clathrin-coated endocytic vesicle membrane]
REPS1 [cytosol]
(Homo sapiens)
SGIP1 [cytosol]
(Homo sapiens)
SH3GLs [cytosol]
(Homo sapiens)
SNX9,18 [cytosol]
(Homo sapiens)
SYNJs,OCRL [cytosol]
(Homo sapiens)
TRIP10 dimer [cytosol]
(Homo sapiens)
WASL,CTTN [cytosol]
(Homo sapiens)
Participates
as an event of
Clathrin-mediated endocytosis (Homo sapiens)
Authored
Rothfels, K (2016-05-11)
Reviewed
Antonescu, CN (2016-05-10)
Created
Rothfels, K (2016-05-04)
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