PLA1A hydrolyses PS to 2-acyl LPS

Stable Identifier
R-HSA-8869425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipase A1 member A (PLA1A, aka PS-PLA1) is a widely expressed, extracellular protein belonging to the pancreatic lipase family. Phospholipases are conserved in a wide range of organisms. PLA1A specifically hydrolyses PS to produce its corresponding lysophospholipid 2-acyl LPS. Lysophospholipids in general can act as lipid mediators with multiple biological functions so PLA1A could play an important role in mediating 2-acyl LPS production (Nagai et al. 1999, Aoki et al. 2007).

Literature References
PubMed ID Title Journal Year
17101204 Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family

Aoki, J, Inoue, A, Makide, K, Saiki, N, Arai, H

Biochimie 2007
10196188 An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans

Nagai, Y, Aoki, J, Sato, T, Amano, K, Matsuda, Y, Arai, H, Inoue, K

J. Biol. Chem. 1999
Participants
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Catalyst Activity
Catalyst Activity
Title
phosphatidylserine 1-acylhydrolase activity of PLA1A [extracellular region]
Physical Entity
Activity
Orthologous Events
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