Reactome | SYT9 [clathrin-coated endocytic vesicle membrane]

SYT9 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869121

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Synaptotagmin-9, SYT9_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86SS6 SYT9

Gene Names

SYT9

Chain

chain:1-491

Reference Genes

BioGPS Gene:143425 SYT9

COSMIC (genes):SYT9 SYT9

CTD Gene:143425 SYT9

dbSNP Gene:143425 SYT9

ENSEMBL:ENSG00000170743 SYT9

ENSEMBL_homo_sapiens_GENE:ENSG00000170743.17 SYT9

HGNC:19265 SYT9

KEGG Gene (Homo sapiens):143425 SYT9

Monarch:143425 SYT9

NCBI Gene:143425 SYT9

OMIM:613528 SYT9

UCSC:Q86SS6 SYT9

Reference Transcript

RefSeq:NM_175733.3 SYT9

Other Identifiers

11745372_a_at

11755823_a_at

143425

1555052_PM_a_at

1555052_a_at

1563658_PM_a_at

1563658_a_at

16721571

232445_PM_at

232445_at

3319076

3319077

3319078

3319087

3319088

3319100

3319103

3319105

3319111

3319112

3319113

3319114

3319121

7938213

84922_at

A_14_P108766

A_24_P255471

A_24_P343736

A_32_P453971

A_33_P3322870

GE580123

GO:0000149

GO:0001786

GO:0005509

GO:0005515

GO:0005544

GO:0005546

GO:0005886

GO:0008289

GO:0014059

GO:0016020

GO:0016192

GO:0017156

GO:0017158

GO:0023052

GO:0030276

GO:0030669

GO:0030672

GO:0031045

GO:0031410

GO:0042802

GO:0043226

GO:0045202

GO:0046872

GO:0061024

GO:0070382

GO:0071277

GO:0098686

GO:0099502

HMNXSV003026426

Hs.177193.0.S1_3p_at

Hs2.177193.3.S1_3p_s_at

ILMN_1728496

PH_hs_0010532

TC11000148.hg

Participates

as a component of

SYT9 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

SYT9 [plasma membrane]

SYT9 [synaptic vesicle membrane]

Inferred To

SYT9 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

SYT9 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

SYT9 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

SYT9 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

SYT9 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Cross References

RefSeq

NP_783860.1

OpenTargets

ENSG00000170743

GeneCards

Q86SS6

HPA

ENSG00000170743-SYT9

Ensembl

ENST00000318881, ENSP00000324419, ENSG00000170743

PRO

Q86SS6

Pharos - Targets

Q86SS6

HMDB Protein

HMDBP08035

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