Reactome | KIAA0319 [clathrin-coated endocytic vesicle membrane]

KIAA0319 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869092

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Dyslexia-associated protein KIAA0319, K0319_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        KIAA0319 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5VV43 KIAA0319

Gene Names

KIAA0319

Chain

signal peptide:1-20, chain:21-1072

Reference Genes

BioGPS Gene:9856 KIAA0319

COSMIC (genes):KIAA0319 KIAA0319

CTD Gene:9856 KIAA0319

dbSNP Gene:9856 KIAA0319

ENSEMBL:ENSG00000137261 KIAA0319

HGNC:21580 KIAA0319

KEGG Gene (Homo sapiens):9856 KIAA0319

Monarch:9856 KIAA0319

NCBI Gene:9856 KIAA0319

OMIM:609269 KIAA0319

UCSC:Q5VV43 KIAA0319

Reference Transcript

Other Identifiers

0000670440

0001170079

11740304_a_at

11740305_at

11740306_a_at

15607

17016160

206017_at

2945599

2945600

2945601

2945602

2945603

2945604

2945606

2945607

2945609

2945610

2945611

2945612

2945614

2945615

2945616

2945617

2945618

2945619

2945620

2945622

2945624

2945625

2945626

2945627

2945628

2945629

2945632

2945633

2945634

2945639

2945640

2945642

2945644

2E7M

39589_at

76313

8124240

9856

A0A087X0U9

A_23_P168324

A_24_P166397

AAI40822

AAI44629

AAI52461

AB002317

AK295008

AK296310

AK296426

AL031230

AL512385

BAA20777

BAG58068

BAG59008

BAG59087

BC140821

BC144628

BC152460

CCDS34348

CCDS54969

CCDS54970

CCDS54971

ENSG00000137261

ENSP00000367459

ENSP00000401086

ENSP00000437656

ENSP00000439700

ENSP00000442403

ENST00000378214

ENST00000378214.7

ENST00000430948

ENST00000430948.6

ENST00000535378

ENST00000535378.5

ENST00000537886

ENST00000537886.5

ENST00000543707

ENST00000543707.2

EntrezGene:9856

EntrezGene:KIAA0319

g7662053_3p_at

GE53053

GO:0001764

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0006950

GO:0007275

GO:0007399

GO:0008150

GO:0010996

GO:0016020

GO:0016021

GO:0030154

GO:0030665

GO:0031410

GO:0031901

GO:0033555

GO:0040011

GO:0043226

GO:0043231

GO:0048856

GO:0048870

GO:0061024

GO:2000171

HGNC:21580

HPA015607

HPA076313

ILMN_1657497

IPR000601

IPR002859

IPR003961

IPR011106

IPR013783

IPR013980

IPR022409

IPR035986

KIAA0319

KIAA0319-201

KIAA0319-202

KIAA0319-203

KIAA0319-204

KIAA0319-205

MIM:609269

NM_001168374

NM_001168375

NM_001168376

NM_001168377

NM_001350403

NM_001350404

NM_001350405

NM_001350406

NM_001350407

NM_001350408

NM_001350409

NM_001350410

NM_014809

NP_001161846

NP_001161847

NP_001161848

NP_001161849

NP_001337332

NP_001337333

NP_001337334

NP_001337335

NP_001337336

NP_001337337

NP_001337338

NP_001337339

NP_055624

PF02010

PH_hs_0002330

SM00060

SM00089

SM00765

TC06001326.hg

UPI000020D61A

UPI0000E09DC4

UPI00018E1816

UPI0001BE8118

XM_011515026

XM_017011541

XM_017011542

XM_017011544

XM_017011546

XM_017011547

XM_017011550

XM_017011551

XP_011513328

XP_016867030

XP_016867031

XP_016867033

XP_016867035

XP_016867036

XP_016867039

XP_016867040

XR_001743779

XR_001743780

Participant Of

hasComponent

KIAA0319 dimer [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

KIAA0319 [plasma membrane]

Inferred To

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

KIAA0319 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001161846.1, XP_011513328.1, XP_011513327.1, NP_055624.2, XP_016867034.1, XP_016867030.1, NP_001161849.1, NP_001161848.1, NP_001161847.1

OpenTargets

ENSG00000137261

GeneCards

Q5VV43

PRO

Q5VV43

PDB

2E7M