Reactome | CHRM2 [clathrin-coated endocytic vesicle membrane]

CHRM2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869085

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

M2, RecName: Full=Muscarinic acetylcholine receptor M2;
GN Name=CHRM2;
OS Homo sapiens, ACM2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08172 CHRM2

Gene Names

CHRM2

Chain

chain:1-466

Reference Genes

BioGPS Gene:1129 CHRM2

COSMIC (genes):CHRM2 CHRM2

CTD Gene:1129 CHRM2

dbSNP Gene:1129 CHRM2

ENSEMBL:ENSG00000181072 CHRM2

ENSEMBL_homo_sapiens_GENE:ENSG00000181072.12 CHRM2

HGNC:1951 CHRM2

KEGG Gene (Homo sapiens):1129 CHRM2

Monarch:1129 CHRM2

NCBI Gene:1129 CHRM2

OMIM:118493 CHRM2

UCSC:P08172 CHRM2

Reference Transcript

Other Identifiers

1129

11737125_a_at

11740620_a_at

17052060

221330_PM_at

221330_at

3026225

3026226

3026227

3026228

3026260

3026265

3026267

3026268

3026269

3026270

3026271

3026272

3026289

48879_at

8136448

A_14_P133775

A_23_P145606

GE80946

GO:0003012

GO:0003013

GO:0004930

GO:0004993

GO:0005886

GO:0006940

GO:0007165

GO:0007186

GO:0007187

GO:0007188

GO:0007197

GO:0007207

GO:0007213

GO:0007268

GO:0007399

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030054

GO:0030425

GO:0030669

GO:0031410

GO:0032279

GO:0032280

GO:0042734

GO:0043025

GO:0043226

GO:0043679

GO:0045202

GO:0045211

GO:0048856

GO:0060089

GO:0095500

GO:0098664

GO:0098978

GO:0098981

GO:0099171

GO:1990763

HMNXSV003014857

ILMN_1729402

ILMN_1761574

ILMN_2358718

M16404_at

PH_hs_0036167

TC07000852.hg

TC07002612.hg

g4502816_3p_at

Participates

as a member of

ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

CHRM2 [plasma membrane]

Inferred To

Homologues of CHRM2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Chrm2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

CHRM2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CHRM2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

mAChR-A [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001006633.1, NP_001006627.1, NP_000730.1, NP_001006631.1, NP_001006630.1, NP_001006629.1, NP_001006632.1, NP_001006628.1, XP_011514071.1

ZINC - World Drugs

ACM2_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000181072

ZINC - FDA approved

ACM2_HUMAN

ZINC - Substances

ACM2_HUMAN

ZINC target

P08172

ZINC - Biogenic

ACM2_HUMAN

PRO

P08172

PDB

5ZKB, 7T94, 3UON, 5ZKC, 8J8R, 8JAF, 7T8X, 4MQS, 6U1N, 5ZK8, 5YC8, 7T90, 8J97, 7T96, 5ZK3, 4MQT, 6OIK

ZINC - Investigational

ACM2_HUMAN

ZINC - Metabolites

ACM2_HUMAN

HPA

ENSG00000181072-CHRM2

GeneCards

P08172

Ensembl

ENSG00000181072, ENST00000445907, ENSP00000399745, ENST00000320658, ENSP00000505686, ENST00000680005, ENST00000401861, ENSP00000415386, ENSP00000319984, ENST00000453373, ENSP00000384401

Pharos - Targets

P08172

ZINC - Predictions - Purchasable

ACM2_HUMAN

Orphanet

27704

HMDB Protein

HMDBP10810

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