Reactome | rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

Stable Identifier

R-HSA-8868773

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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rRNA processing in the nucleus and cytosol

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Each eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 28S rRNA are produced by endonucleolytic and exonucleolytic processing of a single 47S precursor (pre-rRNA) (reviewed in Henras et al. 2015). Transcription of ribosomal RNA genes, processing of pre-rRNA, modification of nucleotide residues within the rRNA, and assembly of precursor 60S and 40S subunits occur predominantly in the nucleolus (reviewed in Hernandez-Verdun et al. 2010, Boschi-Muller and Motorin 2013), with a few late reactions occurring in the cytosol.

Literature References

PubMed ID	Title	Journal	Year
24490730	Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification Boschi-Muller, S, Motorin, Y	Biochemistry Mosc.	2013
25346433	An overview of pre-ribosomal RNA processing in eukaryotes Henras, AK, Plisson-Chastang, C, O'Donohue, MF, Chakraborty, A, Gleizes, PE	Wiley Interdiscip Rev RNA	2015
21956940	The nucleolus: structure/function relationship in RNA metabolism Hernandez-Verdun, D, Roussel, P, Thiry, M, Sirri, V, Lafontaine, DL	Wiley Interdiscip Rev RNA	2010