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p-S22, S392-LMNA-1 [nucleoplasm]
Stable Identifier
R-HSA-8868349
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S22, S392-Lamin A
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates lamin A (Homo sapiens)
p-S22, S392-LMNA-1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02545-1 LMNA
Gene Names
LMNA, LMN1
Other Identifiers
0001740242
0002970021
11719260_x_at
11719261_s_at
11752340_x_at
11752506_s_at
11752507_x_at
11752673_x_at
1554600_s_at
16671914
203411_s_at
212086_x_at
212089_at
2361280
2361282
2361283
2361298
2361299
2361300
2361301
2361302
2361303
2361308
2361309
2361312
2361313
2361314
2361316
2361317
2361320
2361322
2361323
2361325
2361327
2361329
2361330
2361331
2361334
2361335
2361337
2361338
37377_i_at
37378_r_at
4000
71746_s_at
7906085
A_14_P114205
A_23_P34835
A_24_P162718
A_33_P3311285
A_33_P3408762
GE81529
GO:0000278
GO:0003674
GO:0005198
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005638
GO:0005652
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0006259
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006950
GO:0006997
GO:0006998
GO:0007005
GO:0007010
GO:0007049
GO:0007084
GO:0007165
GO:0007517
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0010628
GO:0015031
GO:0016363
GO:0016604
GO:0016607
GO:0030154
GO:0030334
GO:0030951
GO:0031647
GO:0031965
GO:0032204
GO:0034504
GO:0034613
GO:0034641
GO:0035861
GO:0036498
GO:0040011
GO:0042592
GO:0042802
GO:0043226
GO:0048471
GO:0048856
GO:0048870
GO:0051276
GO:0055015
GO:0061024
GO:0071456
GO:0072201
GO:0090201
GO:0090343
GO:0140014
GO:1900114
GO:1900180
GO:1903243
GO:1990683
GO:2001237
HMNXSV003021995
HMNXSV003040267
HMNXSV003043843
HMNXSV003044458
Hs.77886.1.S1_3p_a_at
Hs.77886.2.S2_3p_at
Hs2.377973.4.S1_3p_s_at
ILMN_1696749
ILMN_1737394
M13452_s_at
PH_hs_0025504
g5031874_3p_a_at
Participates
as an output of
CDK5:p25 phosphorylates lamin A (Homo sapiens)
Other forms of this molecule
LMNA-1 [cytosol]
p-S22, S395-LMNA-1 [nucleoplasm]
p-S395-LMNA-1 [nucleoplasm]
LMNA(231-664) [nuclear envelope]
LMNA(1-230) [nuclear envelope]
Lamin A [nucleoplasm]
Modified Residues
Name
O-phospho-L-serine at 22
Coordinate
22
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 392
Coordinate
392
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001269554.1
,
NP_733822.1
,
NP_733821.1
,
NP_001269555.1
,
NP_005563.1
,
NP_001269553.1
,
NP_001244303.1
OpenTargets
ENSG00000160789
HPA
ENSG00000160789-LMNA
GeneCards
P02545
Ensembl
ENSP00000357282
,
ENSG00000160789
,
ENSP00000357283
,
ENST00000368300
,
ENST00000368301
,
ENSP00000357284
,
ENST00000448611
,
ENST00000473598
,
ENSP00000421821
,
ENSP00000395597
,
ENST00000368299
PRO
P02545
Pharos - Targets
P02545
GlyGen
P02545
Orphanet
16364
PDB
1X8Y
,
6YJD
,
6GHD
,
6RPR
,
7CRG
,
3V4W
,
6YF5
,
6JLB
,
2YPT
,
1IFR
,
6SNZ
,
3GEF
,
3V4Q
,
2XV5
,
1IVT
,
3V5B
Interactors (85)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20700 LMNB1
8
LMNB1 [nucleoplasm]
(R-HSA-264867)
LMNB1(1-231) [nuclear envelope]
(R-HSA-352244)
LMNB1(232-586) [nuclear envelope]
(R-HSA-352248)
p-S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5228738)
p-S23, S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5229018)
LMNB1 [cytosol]
(R-HSA-2995384)
LMNB1(2-586) [nuclear envelope]
(R-HSA-912402)
p-S23,S393-LMNB1 [nucleoplasm]
(R-HSA-8868341)
0.849
10
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.799
7
UniProt:Q9UII6 DS13B
0.781
7
UniProt:Q03252 LMNB2
0.713
6
UniProt:O75694 NUP155
2
NUP155 [cytosol]
(R-HSA-9634170)
NUP155 [nuclear envelope]
(R-HSA-157690)
0.672
6
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.666
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.643
13
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.641
4
UniProt:P42166 TMPO
0.629
4
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.629
4
UniProt:P16104 H2AX
7
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
H2AFX [nucleoplasm]
(R-HSA-56151)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [extracellular region]
(R-HSA-977583)
0.604
3
UniProt:Q0D2I5-5 IFFO1
0.576
4
UniProt:P42167 TMPO
1
TMPO [cytosol]
(R-HSA-9714330)
0.569
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:P62701 RPS4X
2
RPS4X [nucleoplasm]
(R-HSA-6798713)
RPS4X [cytosol]
(R-HSA-72375)
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q96LX8 ZNF597
1
ZNF597 [nucleoplasm]
(R-HSA-2127591)
0.556
3
UniProt:Q8WXF7 ATLA1
0.556
3
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q9C0F3 ZNF436
1
ZNF436 [nucleoplasm]
(R-HSA-1247538)
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:Q9NWB1-5 RBFOX1
0.556
3
UniProt:Q6ZNH5 ZN497
0.556
3
UniProt:Q14585 ZN345
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
IntAct:EBI-25842396 CCSB
0.556
3
UniProt:Q04323-2 UBXN1
0.556
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q9BS31 ZNF649
1
ZNF649 [nucleoplasm]
(R-HSA-2127585)
0.556
3
UniProt:O43309 ZSC12
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q7Z3I7 ZN572
0.556
3
UniProt:Q9Y4E8-2 USP15
0.556
3
UniProt:Q96EL1 INKA1
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q9HBE1-4 PATZ1
0.556
3
UniProt:Q6H8Q1-8 ABLIM2
0.556
3
UniProt:Q8N0Y2-2 ZNF444
0.556
3
UniProt:Q9BZ95-3 Q9BZ953
0.556
3
UniProt:A6H8Z2-3 A6H8Z23
0.556
3
UniProt:O76041 NEBL
0.556
3
UniProt:Q99612 KLF6
0.556
3
UniProt:Q96GN5-2 CDCA7L
0.556
3
UniProt:Q96KP6 TNIP3
1
TNIP3 [cytosol]
(R-HSA-561192)
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:Q8NEA9 GMCL2
0.556
3
UniProt:Q12986 NFX1
0.556
3
UniProt:Q5VYS8-5 TUT7
0.556
3
UniProt:Q03181-2 PPARD
0.556
3
UniProt:Q8NA54 IQUB
0.556
3
UniProt:Q8WVD3 RNF138
1
RNF138 [cytosol]
(R-HSA-976008)
0.556
3
UniProt:Q8TBZ8 ZNF564
1
ZNF564 [nucleoplasm]
(R-HSA-1973885)
0.556
3
UniProt:Q8TCX5 RHPN1
1
RHPN1 [cytosol]
(R-HSA-5667017)
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
UniProt:Q15776 ZKSCAN8
1
ZKSCAN8 [nucleoplasm]
(R-HSA-974985)
0.556
3
UniProt:Q6ZNE9 RUFY4
0.556
3
UniProt:P54274-2 TERF1
0.556
3
UniProt:P58499 FAM3B
0.556
3
UniProt:P10073 ZSC22
0.556
3
UniProt:P10074 TZAP
0.556
3
UniProt:Q13133-3 NR1H3
0.556
3
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.556
3
UniProt:Q6X4W1-6 NSMF
0.556
3
IntAct:EBI-25851697 CCSB
0.556
3
UniProt:Q3SX64 OD3L2
0.556
3
UniProt:Q6ZN57 ZFP2
1
ZFP2 [nucleoplasm]
(R-HSA-975018)
0.556
3
UniProt:Q13123 RED
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:Q96DX5 ASB9
1
ASB9 [cytosol]
(R-HSA-975424)
0.556
3
UniProt:Q9ULD4-2 Q9ULD42
0.556
3
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q8WW38 ZFPM2
1
ZFPM2 [nucleoplasm]
(R-HSA-996726)
0.556
3
UniProt:Q9D666 Sun1
1
Sun1 [nuclear envelope]
(R-MMU-912375)
0.528
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
3
UniProt:P18054 ALOX12
1
ALOX12 [cytosol]
(R-HSA-2142768)
0.508
4
UniProt:Q8NC56 LEMD2
1
LEMD2 [nuclear envelope]
(R-HSA-3067329)
0.491
2
UniProt:Q8WXH0-1 SYNE2
0.463
3
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