Reactome | p-S22, S392-LMNA-1 [nucleoplasm]

p-S22, S392-LMNA-1 [nucleoplasm]

Stable Identifier

R-HSA-8868349

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S22, S392-Lamin A

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        CDK5:p25 phosphorylates lamin A (Homo sapiens)
        
        p-S22, S392-LMNA-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02545-1 LMNA

Gene Names

LMNA, LMN1

Other Identifiers

11719260_x_at

11719261_s_at

11752340_x_at

11752506_s_at

11752507_x_at

11752673_x_at

1554600_PM_s_at

1554600_s_at

16671914

203411_PM_s_at

203411_s_at

212086_PM_x_at

212086_x_at

212089_PM_at

212089_at

2361280

2361282

2361283

2361286

2361287

2361288

2361298

2361299

2361300

2361301

2361302

2361303

2361308

2361309

2361312

2361313

2361314

2361316

2361317

2361320

2361322

2361323

2361325

2361327

2361329

2361330

2361331

2361334

2361335

2361337

2361338

37377_i_at

37378_r_at

4000

71746_s_at

7906085

A_14_P114205

A_23_P34835

A_33_P3311285

A_33_P3408762

GE81529

GO:0003012

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005694

GO:0005829

GO:0005856

GO:0005882

GO:0006325

GO:0006606

GO:0006886

GO:0006913

GO:0006997

GO:0006998

GO:0007005

GO:0007010

GO:0007097

GO:0007163

GO:0007517

GO:0008104

GO:0008285

GO:0010628

GO:0012501

GO:0016363

GO:0016607

GO:0023052

GO:0030154

GO:0030334

GO:0030951

GO:0031507

GO:0031647

GO:0031965

GO:0032200

GO:0032204

GO:0034504

GO:0035861

GO:0042802

GO:0043226

GO:0048471

GO:0048856

GO:0048870

GO:0051664

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090398

GO:0090435

GO:1900180

GO:1903243

GO:1990683

GO:2001237

HMNXSV003021995

HMNXSV003040267

HMNXSV003043843

HMNXSV003044458

Hs.77886.1.S1_3p_a_at

Hs.77886.2.S2_3p_at

Hs2.377973.4.S1_3p_s_at

ILMN_1696749

ILMN_1737394

M13452_s_at

PH_hs_0025504

g5031874_3p_a_at

Participates

as an output of

CDK5:p25 phosphorylates lamin A (Homo sapiens)

Other forms of this molecule

p-S22, S395-LMNA-1 [nucleoplasm]

p-S395-LMNA-1 [nucleoplasm]

LMNA-1 [cytosol]

LMNA(231-664) [nuclear envelope]

LMNA(1-230) [nuclear envelope]

Lamin A [nucleoplasm]

Modified Residues

Name

O-phospho-L-serine at 22

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 392

Coordinate

392

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001244303.1, NP_005563.1, NP_733821.1, NP_001269554.1, NP_001269555.1, NP_733822.1, NP_001269553.1

OpenTargets

ENSG00000160789

GeneCards

P02545

HPA

ENSG00000160789-LMNA

Ensembl

ENSP00000355292, ENST00000675939, ENST00000676385, ENSP00000357282, ENST00000683032, ENSP00000503633, ENSP00000421821, ENSP00000506904, ENST00000448611, ENST00000677389, ENSP00000357284, ENST00000473598, ENSP00000395597, ENST00000682650, ENSP00000502256, ENSP00000502091, ENSP00000357283, ENSP00000506771, ENSG00000160789, ENST00000361308, ENST00000368301, ENST00000368300, ENST00000368299

PRO

P02545

Pharos - Targets

P02545

Orphanet

16364

PDB

6GHD, 7D9N, 7Z21, 3GEF, 2YPT, 1X8Y, 1IVT, 3V4W, 7CRG, 6RPR, 6JLB, 2XV5, 6SNZ, 1IFR, 7X5D, 3V5B, 3V4Q, 6YJD, 6YF5

Interactors (84)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.849	10
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.799	7
UniProt:Q9UII6 DS13B			0.781	7
UniProt:Q03252 LMNB2			0.713	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:O75694 NUP155	2	NUP155 [cytosol] (R-HSA-9634170) NUP155 [nuclear envelope] (R-HSA-157690)	0.672	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.666	4
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.641	4
UniProt:P42166 TMPO			0.629	4
UniProt:P16104 H2AX	7	K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.604	3
UniProt:Q0D2I5-5 IFFO1			0.576	4
UniProt:P42167 TMPO	1	TMPO [cytosol] (R-HSA-9714330)	0.569	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q8WW38 ZFPM2	1	ZFPM2 [nucleoplasm] (R-HSA-996726)	0.556	3
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9NWB1-5 RBFOX1			0.556	3
UniProt:Q14585 ZN345			0.556	3
UniProt:Q6ZNH5 ZN497			0.556	3
IntAct:EBI-25842396 CCSB			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.556	3
UniProt:O43309 ZSC12			0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q9Y4E8-2 USP15			0.556	3
UniProt:Q96EL1 INKA1			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q6H8Q1-8 ABLIM2			0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:A6H8Z2-3 A6H8Z23			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q99612 KLF6			0.556	3
UniProt:Q96GN5-2 CDCA7L			0.556	3
UniProt:Q96KP6 TNIP3	1	TNIP3 [cytosol] (R-HSA-561192)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q12986 NFX1			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q03181-2 PPARD			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.556	3
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:Q6ZNE9 RUFY4			0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:P58499 FAM3B			0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:Q13133-3 NR1H3			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q3SX64 OD3L2			0.556	3
UniProt:Q6ZN57 ZFP2	1	ZFP2 [nucleoplasm] (R-HSA-975018)	0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:Q8WXH0-1 SYNE2			0.463	3

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