Reactome | PRPF38A [nucleoplasm]

PRPF38A [nucleoplasm]

Stable Identifier

R-HSA-8867897

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor 38A, PR38A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15329 E2F5

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External Reference Information

External Reference

UniProt:Q8NAV1 PRPF38A

Gene Names

PRPF38A

Chain

chain:1-312

Reference Genes

BioGPS Gene:84950 PRPF38A

COSMIC (genes):PRPF38A PRPF38A

CTD Gene:84950 PRPF38A

dbSNP Gene:84950 PRPF38A

ENSEMBL:ENSG00000134748 PRPF38A

ENSEMBL_homo_sapiens_GENE:ENSG00000134748.13 PRPF38A

HGNC:25930 PRPF38A

KEGG Gene (Homo sapiens):84950 PRPF38A

Monarch:84950 PRPF38A

NCBI Gene:84950 PRPF38A

UCSC:Q8NAV1 PRPF38A

Reference Transcript

RefSeq:NM_032864.3 PRPF38A

Other Identifiers

11743069_a_at

11743070_at

1553709_PM_a_at

1553709_a_at

16664731

223230_PM_at

223230_at

2336384

2336385

2336387

2336388

2336389

2336390

2336392

2336395

2336396

2336398

2336399

2336401

2336402

2336403

2336404

2336405

2336406

2336407

2336409

2336411

2336413

235612_PM_at

235612_at

3237076

3237083

45968_at

7901447

83593_at

84950

87910_s_at

A_14_P202139

A_24_P88493

A_24_P97001

GE83362

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0016071

GO:0043226

GO:0071005

GO:0071011

HMNXSV003008195

Hs.34644.0.A1_3p_at

Hs.5301.0.S2_3p_at

Hs2.5301.2.S1_3p_s_at

ILMN_1656274

ILMN_1675626

PH_hs_0000542

TC01000641.hg

Participates

as an input of

Formation of the Spliceosomal B complex (Homo sapiens)

as an output of

Formation of the Spliceosomal Bact complex (Homo sapiens)

as a component of

Spliceosomal B complex [nucleoplasm] (Homo sapiens)

Inferred To

prp38 [nucleoplasm] (Schizosaccharomyces pombe)

PRPF38A [nucleoplasm] (Bos taurus)

PRPF38A [nucleoplasm] (Canis familiaris)

PRPF38A [nucleoplasm] (Gallus gallus)

PRPF38A [nucleoplasm] (Plasmodium falciparum)

PRPF38A [nucleoplasm] (Sus scrofa)

Prpf38a [nucleoplasm] (Mus musculus)

Prpf38a [nucleoplasm] (Rattus norvegicus)

prp-38 [nucleoplasm] (Caenorhabditis elegans)

prpf38a [nucleoplasm] (Dictyostelium discoideum)

prpf38a [nucleoplasm] (Xenopus tropicalis)

Prp38 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_116253.2

OpenTargets

ENSG00000134748

GeneCards

Q8NAV1

HPA

ENSG00000134748-PRPF38A

Ensembl

ENST00000257181, ENSG00000134748, ENSP00000257181

PRO

Q8NAV1

Pharos - Targets

Q8NAV1

PDB

7ABG, 4RZ9, 4RZA, 8Q7N, 5O9Z, 5F5S, 7ABF, 6AHD, 7AAV, 8QO9, 7ABI

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.855	7
UniProt:Q9H190 SDCB2			0.781	7
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.693	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.671	4
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.641	3
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.632	5
UniProt:P49760 CLK2			0.556	3
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.556	3
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	5
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994)	0.527	3
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.508	2
UniProt:Q9Y6A4 CFA20			0.508	2
UniProt:Q9NVR5 KTU			0.508	2
UniProt:Q15329 E2F5	1	E2F5 [nucleoplasm] (R-HSA-68669)	0.508	2
UniProt:P23527 H2BC17	9	Ub-HIST1H2BO [nucleoplasm] (R-HSA-6782549) AcK-HIST1H2BO [nucleoplasm] (R-HSA-4549268) HIST1H2BO [extracellular region] (R-HSA-977557) AcK13-HIST1H2BO [nucleoplasm] (R-HSA-4568712) AcK21-HIST1H2BO [nucleoplasm] (R-HSA-4568713) AcK16-HIST1H2BO [nucleoplasm] (R-HSA-4568681) AcK6-HIST1H2BO [nucleoplasm] (R-HSA-4568708) Ub-121-HIST1H2BO [nucleoplasm] (R-HSA-3364033) HIST1H2BO [nucleoplasm] (R-HSA-181910)	0.508	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.508	2
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.508	2
UniProt:Q13247 SRSF6	1	SRSF6 [nucleoplasm] (R-HSA-72026)	0.508	2

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