Reactome | PRPF40A [nucleoplasm]

PRPF40A [nucleoplasm]

Stable Identifier

R-HSA-8867890

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-processing factor 40 homolog A, PR40A_HUMAN, FBP11

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75400 PRPF40A

Gene Names

PRPF40A, FBP11, FLAF1, FNBP3, HIP10, HYPA, HSPC225

Chain

chain:1-957

Reference Genes

BioGPS Gene:55660 PRPF40A

COSMIC (genes):PRPF40A PRPF40A

CTD Gene:55660 PRPF40A

dbSNP Gene:55660 PRPF40A

ENSEMBL:ENSG00000196504 PRPF40A

HGNC:16463 PRPF40A

KEGG:hsa:55660 PRPF40A

Monarch:55660 PRPF40A

NCBI Gene:55660 PRPF40A

OMIM:612941 PRPF40A

UCSC:O75400 PRPF40A

Reference Transcript

RefSeq:NM_017892.3 PRPF40A

Participates

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

as a component of

as an output of

Formation of the Spliceosomal B complex (Homo sapiens)

Inferred To

prp40 [nucleoplasm] (Dictyostelium discoideum)

prp40 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of PRPF40A [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of PRPF40A [nucleoplasm] (Xenopus tropicalis)

PRPF40A [nucleoplasm] (Bos taurus)

PRPF40A [nucleoplasm] (Caenorhabditis elegans)

PRPF40A [nucleoplasm] (Canis familiaris)

PRPF40A [nucleoplasm] (Gallus gallus)

PRPF40A [nucleoplasm] (Sus scrofa)

Prp40 [nucleoplasm] (Drosophila melanogaster)

Prpf40a [nucleoplasm] (Mus musculus)

Prpf40a [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000196504

ENSEMBL

ENST00000696381, ENSP00000512591, ENSG00000196504, ENSP00000346332, ENST00000354363

GeneCards

PRPF40A

PRO

O75400

Pharos - Targets

O75400

GlyGen

O75400

PDB

2LKS, 1YWJ, 1ZR7, 2CQN, 2L5F, 1UZC, 1YWI, 2KZG, 2L9V, 2DYF, 8PXW, 8PXX

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.743	15
UniProt:Q53F19 NCBP3			0.643	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.632	3
UniProt:P49756 RBM25	1	RBM25 [nucleoplasm] (R-HSA-9770250)	0.564	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.564	2
UniProt:Q9H190 SDCB2			0.553	2
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.553	2
UniProt:Q9NRR5 UBQL4			0.553	2
UniProt:Q8TBK6 ZCH10			0.547	3
UniProt:Q8N3X1 FNBP4			0.547	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.508	2
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.508	2
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.482	3

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