OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane

Stable Identifier
Homo sapiens
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Phosphatidylserine (PS) is a lipid component of cellular membranes. It is synthesised in the endoplasmic reticulum and then preferentially associates with the inner leaflet of the plasma membrane by as-yet unknown mechanisms. Intracellular lipids can travel through aqueous phases via transport vesicles or lipid-transfer proteins (LTPs). Oxysterol-binding protein-related proteins 5, 8 and 10 (OSBPL5, OSBPL8 and OSBPL10) bind and transport PS from ER compartments to the plasma membrane. They tether the ER to the plasma membrane via interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) and mediate PI4P/PS countertransport between the ER and the plasma membrane (Du et al. 2011, Chung et al. 2015, Perttila et al. 2009, Maeda et al. 2013). OSBPL10 is also implicated in apolipoprotein B100 secretion (Nissila et al. 2012).

Literature References
PubMed ID Title Journal Year
22906437 ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion

Perttilä, J, Ohsaki, Y, Olkkonen, VM, Nissilä, E, Ikonen, E, Weber-Boyvat, M

Biochim. Biophys. Acta 2012
19554302 OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism

Salomaa, V, Merikanto, K, Perttilä, J, Naukkarinen, J, Olkkonen, VM, Martin, NW, Grimard, V, Tanhuanpää, K, Virtanen, I, Taskinen, MR, Thiele, C, Surakka, I, Peltonen, L, Jula, A, Perola, M

J. Mol. Med. 2009
21220512 A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking

Prinz, WA, Hong, W, Du, X, Parton, RG, Brown, AJ, Ong, YS, Ferguson, C, Yang, H, Schulz, TA, Kumar, J

J. Cell Biol. 2011
23934110 Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

Maeda, K, Gavin, AC, Poletto, M, Kumar, A, Chiapparino, A, Kaksonen, M, Anand, K

Nature 2013
26206935 INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

Narayanaswamy, P, Lucast, L, Chung, J, Wenk, MR, Masai, K, Torta, F, De Camilli, P, Nakatsu, F, Tanner, LB, Czapla, H

Science 2015
Catalyst Activity

phospholipid transporter activity of OSBPL5,8,10 [cytosol]

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