Reactome | Polyglutamyl-TUBB1 [cytosol]

Polyglutamyl-TUBB1 [cytosol]

Stable Identifier

R-HSA-8867413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB1, beta tubulin 1

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB1 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB1 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H4B7 TUBB1

Gene Names

TUBB1

Chain

chain:1-451

Reference Genes

BioGPS Gene:81027 TUBB1

COSMIC (genes):TUBB1 TUBB1

CTD Gene:81027 TUBB1

dbSNP Gene:81027 TUBB1

ENSEMBL:ENSG00000101162 TUBB1

HGNC:16257 TUBB1

KEGG:hsa:81027 TUBB1

Monarch:81027 TUBB1

NCBI Gene:81027 TUBB1

OMIM:612901 TUBB1

UCSC:Q9H4B7 TUBB1

Reference Transcript

RefSeq:NM_030773.3 TUBB1

Other Identifiers

11725897_at

16915395

208601_PM_s_at

208601_s_at

230690_PM_at

230690_at

3891343

3891344

3891345

3891346

3891348

3891349

3891350

3891351

48085_at

8063716

81027

A_14_P103140

A_23_P6034

A_24_P228550

GE543157

GO:0000226

GO:0000278

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007155

GO:0015630

GO:0016787

GO:0030154

GO:0030220

GO:0030878

GO:0043226

GO:0045171

GO:0046785

GO:0046872

GO:0048856

GO:0051225

GO:0065003

GO:0070062

GO:0070327

GO:0070527

GO:0072686

HMNXSV003021293

Hs.303023.1.A1_3p_at

ILMN_1710280

PH_hs_0015644

TC20000468.hg

g13562113_3p_s_at

Participates

as a candidate of

Polyglutamyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB1 folding intermediate [cytosol]

TUBB1 unfolded [cytosol]

Polyglycyl-TUBB1 [cytosol]

TUBB1 [axonemal microtubule]

TUBB1 [cytosol]

Inferred To

TUBB1 [cytosol] (Bos taurus)

TUBB1 [cytosol] (Canis familiaris)

TUBB1 [cytosol] (Sus scrofa)

Tubb1 [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBB1 [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBB1 [cytosol] (Mus musculus)

Polyglutamyl-TUBB1 [cytosol] (Plasmodium falciparum)

tubb1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_110400.1

ENSEMBL

ENST00000217133, ENSP00000217133

OpenTargets

ENSG00000101162

HPA

ENSG00000101162-TUBB1

ZINC - Substances

TBB1_HUMAN

ZINC - Biogenic

TBB1_HUMAN

ZINC target

Q9H4B7

PRO

Q9H4B7

Pharos - Targets

Q9H4B7

Orphanet

TUBB1

ZINC - Predictions - Purchasable

TBB1_HUMAN

HMDB Protein

HMDBP08601

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01008 SERPINC1	8	SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8956773) p-SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8957069) SERPINC1(426-464) [extracellular region] (R-HSA-140817) SERPINC1(33-425) [extracellular region] (R-HSA-140814) SERPINC1 [extracellular region] (R-HSA-140807) SERPINC1 [plasma membrane] (R-HSA-140792) SERPINC1(426-464) [plasma membrane] (R-HSA-140816) SERPINC1(33-425) [plasma membrane] (R-HSA-140815)	0.527	2
UniProt:Q8N307 MUC20	19	MUC20 [plasma membrane] (R-HSA-8851833) GalNAc-MUC20 [plasma membrane] (R-HSA-8858516) Core 2 (MUC20) [Golgi lumen] (R-HSA-1462330) Core 2a (MUC20) [Golgi lumen] (R-HSA-6784267) GalNAc-MUC20 [Golgi lumen] (R-HSA-1463443) Sialyl Tn antigen (MUC20) [Golgi lumen] (R-HSA-1463558) T-antigen (MUC20) [Golgi lumen] (R-HSA-1462188) Sialyl-2,3 T-antigen (MUC20) [Golgi lumen] (R-HSA-1463479) Sialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463469) Disialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463482) MUC20 [Golgi lumen] (R-HSA-913634) Core 6 (MUC20) [Golgi lumen] (R-HSA-1462247) extended Core 6 (MUC20) [Golgi lumen] (R-HSA-1967016) Core 7 (MUC20) [Golgi lumen] (R-HSA-1462236) Core 3 (MUC20) [Golgi lumen] (R-HSA-1462344) Core 4 (MUC20) [Golgi lumen] (R-HSA-1462266) Core 5 (MUC20) [Golgi lumen] (R-HSA-1462128) Core 2S (MUC20) [Golgi lumen] (R-HSA-6786382) Core 8 (MUC20) [Golgi lumen] (R-HSA-1462329)	0.527	2
UniProt:Q9NY25 CLEC5A	3	CLEC5A [tertiary granule membrane] (R-HSA-6801019) CLEC5A [plasma membrane] (R-HSA-210028) CLEC5A [specific granule membrane] (R-HSA-6799520)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q6UWV6 ENPP7	1	ENPP7 [plasma membrane] (R-HSA-1631583)	0.527	2
UniProt:P24387 CRHBP	1	CRHBP [extracellular region] (R-HSA-8937598)	0.527	2
UniProt:O75161 NPHP4	1	NPHP4 [cytosol] (R-HSA-2059925)	0.508	3

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