OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5

Stable Identifier
R-HSA-8867288
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the cytosol for ER-associated degradation (ERAD). The N-glycan is used as a signal to distinguish proteins to be degraded, by direct binding to a ubiquitin ligase complex composed of, minimally, an E3 ubiquitin-protein ligase, protein sel-1 homolog 1 (SEL1L), derlin-2 (DERL2) and protein OS-9 (OS9) (Christianson et al. 2008, Bernasconi et al. 2008, Alcock & Swanton 2009; review Olzmann et al. 2013).
Literature References
PubMed ID Title Journal Year
19084021 Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

Alcock, F, Swanton, E

J. Mol. Biol. 2009
23232094 The mammalian endoplasmic reticulum-associated degradation system

Olzmann, JA, Kopito, RR, Christianson, JC

Cold Spring Harb Perspect Biol 2013
18264092 OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

Christianson, JC, Shaler, TA, Tyler, RE, Kopito, RR

Nat. Cell Biol. 2008
18417469 A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

Bernasconi, R, Pertel, T, Luban, J, Molinari, M

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane]

Physical Entity
OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Authored
Jassal, B  (2010-11-17)
Reviewed
Dall'Olio, GM  (2015-06-22)
Created
Jassal, B  (2016-04-06)
Cite Us!