Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14R) plays a role in the regulation of lipogenesis in the liver. It is rapidly upregulated by processes that induce lipogenesis (enhanced glucose metabolism, thyroid hormone administration) (Tsatsos et al. 2008). MID1IP1 forms a heterodimer with thyroid hormone-inducible hepatic protein (THRSP, aka SPOT14, S14), proposed to play the same role in lipogenesis as MID1IP1 (Aipoalani et al. 2010). This complex can polymerise acetyl-CoA carboxylases 1 and 2 (ACACA and B), the first committed enzymes in fatty acid (FA) synthesis. Polymerisation enhances ACACA and ACACB enzyme activities (Kim et al. 2010, Park et al. 2013).

Literature References
PubMed ID Title Journal Year
24277613 Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2

Park, S, Hwang, IW, Makishima, Y, Perales-Clemente, E, Kato, T, Niederländer, NJ, Park, EY, Terzic, A

J. Mol. Recognit. 2013
20233797 Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis

Aipoalani, DL, O'Callaghan, BL, Mashek, DG, Mariash, CN, Towle, HC

Endocrinology 2010
18556348 Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate

Tsatsos, NG, Augustin, LB, Anderson, GW, Towle, HC, Mariash, CN

Endocrinology 2008
Participant Of
Orthologous Events
Cite Us!