Reactome | MID1IP1 binds THRSP

MID1IP1 binds THRSP

Stable Identifier

R-HSA-8866941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14R) plays a role in the regulation of lipogenesis in the liver. It is rapidly upregulated by processes that induce lipogenesis (enhanced glucose metabolism, thyroid hormone administration) (Tsatsos et al. 2008). MID1IP1 forms a heterodimer with thyroid hormone-inducible hepatic protein (THRSP, aka SPOT14, S14), proposed to play the same role in lipogenesis as MID1IP1 (Aipoalani et al. 2010). This complex can polymerize acetyl-CoA carboxylases 1 and 2 (ACACA and B), the first committed enzymes in fatty acid (FA) synthesis. Polymerization enhances ACACA and ACACB enzyme activities (Kim et al. 2010, Park et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
20233797	Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis Mariash, CN, Mashek, DG, Aipoalani, DL, Towle, HC, O'Callaghan, BL	Endocrinology	2010
24277613	Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2 Hwang, IW, Makishima, Y, Niederländer, NJ, Terzic, A, Kato, T, Perales-Clemente, E, Park, S, Park, EY	J. Mol. Recognit.	2013
18556348	Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate Mariash, CN, Towle, HC, Anderson, GW, Augustin, LB, Tsatsos, NG	Endocrinology	2008