CFTR F508del is degraded by the 26S proteasome

Stable Identifier
R-HSA-8866858
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After VCP-mediated translocation to the cytosol, misfolded CFTR F508del is degraded by the 26S proteasome (El Khouri et al, 2013).

Literature References
PubMed ID Title Journal Year
24019521 RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

El Khouri, E, Le Pavec, G, Toledano, MB, Delaunay-Moisan, A

J. Biol. Chem. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cystic fibrosis 1485 mucoviscidosis, CF
Authored
Reviewed