After VCP-mediated translocation to the cytosol, misfolded CFTR F508del is degraded by the 26S proteasome (El Khouri et al, 2013).
El Khouri, E, Toledano, MB, Le Pavec, G, Delaunay-Moisan, A
endopeptidase activity of 26S proteasome [cytosol]
Gain of function of ub-CFTR F508del [cytosol]
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