CFTR transits to the plasma membrane

Stable Identifier
R-HSA-8866851
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CFTR transits to the plasma membrane
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The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride ion channel that undergoes multiple folding processes and post-translational modifications during its biosynthesis. 60-80% of CFTR protein encoded by the wild-type (WT) gene is successfully modified and transits the secretory system to the plasma membrane. The remaining misfolded protein is targeted for degradation by the ER, lysosomes or autophagy (reviewed in Pranke and Sermet-Gaudelus, 2014)
Literature References
PubMed ID Title Journal Year
24685677 Biosynthesis of cystic fibrosis transmembrane conductance regulator

Sermet-Gaudelus, I, Pranke, IM

Int. J. Biochem. Cell Biol. 2014
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Orthologous Events
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Authored
Rothfels, K  (2016-04-02)
Reviewed
D'Eustachio, P  (2016-04-23)
Created
Rothfels, K  (2016-04-04)
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