Reactome | CFTR F508del [endoplasmic reticulum membrane]

CFTR F508del [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8866834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9NVI7 ATD3A

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External Reference Information

External Reference

UniProt:P13569 CFTR

Gene Names

CFTR, ABCC7

Chain

chain:1-1480

Reference Genes

BioGPS Gene:1080 CFTR

COSMIC (genes):CFTR CFTR

CTD Gene:1080 CFTR

dbSNP Gene:1080 CFTR

ENSEMBL:ENSG00000001626 CFTR

ENSEMBL_homo_sapiens_GENE:ENSG00000001626.18 CFTR

HGNC:1884 CFTR

KEGG Gene (Homo sapiens):1080 CFTR

Monarch:1080 CFTR

NCBI Gene:1080 CFTR

OMIM:602421 CFTR

UCSC:P13569 CFTR

Reference Transcript

RefSeq:NM_000492.3 CFTR

Other Identifiers

1080

11722757_at

17050697

205043_PM_at

205043_at

215702_PM_s_at

215702_s_at

3020647

3020648

3020652

3020654

3020658

3020659

3020661

3020662

3020663

3020664

3020666

3020667

3020668

3020670

3020672

3020673

3020674

3020679

3020680

3020682

3020683

3020684

3020685

3020686

3020688

3020689

3020694

3020695

3020696

3020698

3020699

3020701

3020702

3020705

3020706

3020707

3020712

3020719

3020721

3020722

3020723

3020724

3020725

3020726

3020727

36816_s_at

36817_at

3902164

3902300

8135661

A_14_P104877

A_14_P114787

A_14_P129538

A_14_P132049

A_23_P215720

GE62403

GO:0000166

GO:0003824

GO:0005215

GO:0005254

GO:0005260

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006629

GO:0006695

GO:0006811

GO:0006821

GO:0006904

GO:0009986

GO:0010008

GO:0015106

GO:0015108

GO:0015701

GO:0016020

GO:0016192

GO:0016324

GO:0016787

GO:0016853

GO:0016887

GO:0017081

GO:0019869

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030165

GO:0030301

GO:0030660

GO:0030669

GO:0031410

GO:0031901

GO:0032991

GO:0034220

GO:0034707

GO:0034976

GO:0035377

GO:0035774

GO:0042626

GO:0043225

GO:0043226

GO:0045921

GO:0048240

GO:0048856

GO:0050891

GO:0051087

GO:0051454

GO:0051649

GO:0055037

GO:0055038

GO:0055085

GO:0060081

GO:0070175

GO:0071320

GO:0097186

GO:0098772

GO:0106138

GO:0140359

GO:0140657

GO:1902161

GO:1902476

GO:1902943

GO:1904322

HMNXSV003020096

Hs.663.1.A1_3p_a_at

ILMN_1705813

M55131_at

PH_hs_0024884

TC07000726.hg

g6995995_3p_at

Participates

as a component of

as an input of

Other forms of this molecule

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

PolyUb-CFTR [plasma membrane]

CFTR [lysosomal membrane]

CFTR [Golgi-associated vesicle membrane]

CFTR [endosome membrane]

PolyUb-CFTR [endosome membrane]

ub-CFTR F508del [cytosol]

ub-CFTR F508del [endoplasmic reticulum membrane]

CFTR G542* [plasma membrane]

CFTR G551D [plasma membrane]

CFTR W1282* [plasma membrane]

CFTR F508del [plasma membrane]

CFTR N1303K [plasma membrane]

CFTR [plasma membrane]

CFTR [endoplasmic reticulum membrane]

misfolded CFTR [endoplasmic reticulum membrane]

Modified Residues

Name

Deletion of residues 508 to 508

Disease

Name	Identifier	Synonyms
cystic fibrosis	DOID:1485	mucoviscidosis, CF

Cross References

RefSeq

NP_000483.3

ZINC - World Drugs

CFTR_HUMAN

Guide to Pharmacology - Targets

707

OpenTargets

ENSG00000001626

ZINC - FDA approved

CFTR_HUMAN

ZINC - Substances

CFTR_HUMAN

ZINC - Biogenic

CFTR_HUMAN

ZINC target

P13569

PRO

P13569

PDB

5TFD, 5D3E, 8EIO, 7SVR, 2BBS, 5TFA, 7QI1, 8EIG, 6O1V, 2BBO, 1XMI, 8FZQ, 2LOB, 7SVD, 5TF8, 6GK4, 5TFI, 6ZE1, 5UAK, 8UBR, 2PZG, 7SV7, 6GJQ, 6UK1, 8EJ1, 5TFG, 1XMJ, 8EIQ, 2PZE, 6HEP, 2PZF, 6MSM, 5TFC, 5D3F, 3GD7, 6GKD, 5TFB, 5TF7, 6WBS, 5TFJ, 3ISW, 6GJS, 6O2P, 6GJU, 2BBT, 5TGK, 5D2D, 5TFF, 4WZ6

IntEnz

5.6.1.6

HPA

ENSG00000001626-CFTR

GeneCards

P13569

Ensembl

ENST00000003084, ENST00000649781, ENSP00000497203, ENSG00000001626, ENSP00000003084

Pharos - Targets

P13569

Orphanet

15441

ZINC - Predictions - Purchasable

CFTR_HUMAN

HMDB Protein

HMDBP02121

Interactors (989)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.938	26
UniProt:Q15599 NHRF2			0.93	28
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.889	24
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.888	27
UniProt:O00299 CLIC1			0.788	15
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.788	9
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.788	21
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.788	24
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.774	23
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.774	25
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.774	15
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.774	27
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.774	24
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.77	14
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.767	10
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.749	13
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.745	22
UniProt:P60981 DEST			0.738	16
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.738	15
UniProt:P13667 PDIA4			0.736	18
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.736	15
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.731	6
UniProt:Q01518 CAP1	3	CAP1 [cytosol] (R-HSA-350758) CAP1 [extracellular region] (R-HSA-350746) CAP1 [azurophil granule lumen] (R-HSA-6798752)	0.725	14
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.725	12
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.725	19
UniProt:O95793 STAU1			0.725	13
UniProt:P62158 CALM			0.725	18
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.725	12
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.725	12
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.725	18
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.725	23
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.718	8
UniProt:Q92734 TFG	7	TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG [cytosol] (R-HSA-5688159)	0.707	7
UniProt:O14545 TRAD1			0.707	9
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.706	17
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.706	15
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.706	14
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.706	21
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.706	22
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.706	17
UniProt:Q9UHB6 LIMA1			0.706	22
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.706	16
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.706	13
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.706	21
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [tertiary granule membrane] (R-HSA-6800175)	0.706	13
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.706	22
UniProt:P61160 ACTR2	4	ACTR2 [ficolin-1-rich granule lumen] (R-HSA-6800937) ACTR2 [extracellular region] (R-HSA-6806232) ACTR2 [azurophil granule lumen] (R-HSA-6798740) ACTR2 [cytosol] (R-HSA-200810)	0.706	15
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.706	11
UniProt:O95433 AHSA1			0.706	13
UniProt:O95425 SVIL			0.706	14
UniProt:Q8WWI1 LMO7	3	LMO7(1-1073)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713460) LMO7(1-1073)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713457) LMO7 [cytosol] (R-HSA-8862589)	0.706	17
UniProt:O43852 CALU	3	CALU [endoplasmic reticulum lumen] (R-HSA-350695) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [extracellular region] (R-HSA-350739)	0.706	13
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [cytosol] (R-HSA-3343670)	0.706	17
UniProt:A0FGR8 ESYT2	1	ESYT2 [endoplasmic reticulum membrane] (R-HSA-8857683)	0.706	15
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.706	21
UniProt:Q13045 FLII			0.706	18
UniProt:Q9Y608 LRRF2			0.706	14
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.706	18
UniProt:P17812 CTPS1	1	CTPS1 [cytosol] (R-HSA-73536)	0.706	20
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.706	18
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.706	15
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.706	21
UniProt:Q5T4S7 UBR4	5	UBR4 [specific granule membrane] (R-HSA-6801492) UBR4 [ficolin-1-rich granule membrane] (R-HSA-6801503) UBR4 [plasma membrane] (R-HSA-6801583) UBR4 [tertiary granule membrane] (R-HSA-6801489) UBR4 [cytosol] (R-HSA-976045)	0.706	15
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.706	21
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.706	17
UniProt:P17655 CAPN2	2	CAPN2 [plasma membrane] (R-HSA-8863405) CAPN2 [cytosol] (R-HSA-8848630)	0.706	17
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.706	23
UniProt:P57088 TMM33			0.706	21
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.706	24
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.706	20
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [extracellular region] (R-HSA-349735) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [cytosol] (R-HSA-71492)	0.706	18
UniProt:Q12904 AIMP1	1	AIMP1(1-312) [cytosol] (R-HSA-379609)	0.706	16
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.706	19
UniProt:O75340 PDCD6			0.706	8
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.706	22
UniProt:P37802 TAGLN2	2	TAGLN2 [extracellular region] (R-HSA-8862999) TAGLN2 [cytosol] (R-HSA-8862962)	0.706	20
UniProt:Q14257 RCN2			0.706	18
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.706	22
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.706	21
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.706	13
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.706	19
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.706	23
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.706	12
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.706	21
UniProt:P00338 LDHA	2	PolyUb-LDHA [cytosol] (R-HSA-9861549) LDHA [cytosol] (R-HSA-70502)	0.706	20
UniProt:P35232 PHB	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.706	17
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.706	20
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.706	21
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.706	17
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.706	21
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.706	18
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.706	18
UniProt:Q5T2W1 NHRF3			0.702	6
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.695	8
UniProt:Q6PID8 KLD10			0.677	9
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.677	11
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.677	24
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.665	7
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.659	10
UniProt:Q9QX74 SHAN2			0.658	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.658	17
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.646	6
UniProt:P04632 CAPNS1	2	CAPNS1 [cytosol] (R-HSA-3288229) CAPNS1 [plasma membrane] (R-HSA-3828034)	0.643	5
UniProt:P08107 HSP71			0.643	5
UniProt:P31151 S100A7	2	S100A7 [azurophil granule lumen] (R-HSA-6799207) S100A7 [extracellular region] (R-HSA-5432925)	0.643	10
UniProt:Q9NQH7 XPP3			0.643	8
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.643	11
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.643	11
UniProt:P05109 S100A8	3	S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [cytosol] (R-HSA-9626834) S100A8 [extracellular region] (R-HSA-5432846)	0.643	11
UniProt:P56537 IF6			0.643	11
UniProt:P13987 CD59	8	GPI-CD59 [Golgi membrane] (R-HSA-6808772) GPI-CD59 [transport vesicle] (R-HSA-6808775) GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689804) GPI-CD59 [ER to Golgi transport vesicle membrane] (R-HSA-5689801) GPI-CD59 [endoplasmic reticulum membrane] (R-HSA-5689453) CD59 [specific granule membrane] (R-HSA-6799513) CD59 [tertiary granule membrane] (R-HSA-6800885) CD59 [plasma membrane] (R-HSA-2530458)	0.643	9
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.64	13
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.64	12
UniProt:Q9Y295 DRG1	2	3OHK22-DRG1 [cytosol] (R-HSA-9629587) DRG1 [cytosol] (R-HSA-9629563)	0.64	9
UniProt:P09972 ALDOC	5	ALDOC [secretory granule lumen] (R-HSA-6801483) ALDOC [ficolin-1-rich granule lumen] (R-HSA-6801464) ALDOC [extracellular region] (R-HSA-6801553) ALDOC [tertiary granule lumen] (R-HSA-6801526) ALDOC [cytosol] (R-HSA-70455)	0.64	8
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.64	10
UniProt:P13804 ETFA	1	ETFA(1-?) [mitochondrial matrix] (R-HSA-169262)	0.64	7
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.64	13
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.64	13
UniProt:Q8WWA1 TMM40			0.632	9
UniProt:Q9NUU7 DD19A			0.618	9
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.618	10
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.615	16
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.615	12
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.615	20
UniProt:P11586 MTHFD1	1	MTHFD1 [cytosol] (R-HSA-200641)	0.615	18
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.615	20
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.615	21
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.615	14
UniProt:P61604 HSPE1	2	HSPE1 [cytosol] (R-HSA-9714750) HSPE1 [mitochondrial matrix] (R-HSA-9857069)	0.615	17
UniProt:P40926 MDH2	1	MDH2 [mitochondrial matrix] (R-HSA-70977)	0.615	9
UniProt:P35580 MYH10	1	MYH10 [cytosol] (R-HSA-419174)	0.615	21
UniProt:Q13148 TADBP			0.615	9
UniProt:P13797 PLST			0.615	9
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [cytosol] (R-HSA-380285)	0.615	20
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.615	10
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.615	10
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.615	19
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.615	17
UniProt:Q99829 CPNE1	2	CPNE1 [plasma membrane] (R-HSA-5215998) CPNE1 [azurophil granule membrane] (R-HSA-6799152)	0.615	13
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.615	19
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.615	14
UniProt:P48444 ARCN1	4	ARCN1 [endoplasmic reticulum membrane] (R-HSA-6810948) ARCN1 [Golgi membrane] (R-HSA-6808714) ARCN1 [transport vesicle] (R-HSA-6808717) ARCN1 [cytosol] (R-HSA-199980)	0.615	8
UniProt:O43795 MYO1B			0.615	20
UniProt:Q13310 PABP4			0.615	12
UniProt:Q9P2E9 RRBP1	2	RRBP1(1-1253)insTPERALSSGLH-p-6Y-ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702011) RRBP1(1-1253)insTPERALSSGLH-ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702005)	0.615	10
UniProt:P37108 SRP14	4	SRP14 [cytosol] (R-HSA-264941) SRP14 [secretory granule lumen] (R-HSA-6800938) SRP14 [extracellular region] (R-HSA-6806495) SRP14 [ficolin-1-rich granule lumen] (R-HSA-6800439)	0.615	12
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.615	13
UniProt:O43175 PHGDH	1	PHGDH [cytosol] (R-HSA-977340)	0.615	12
UniProt:Q9Y305 ACOT9	1	ACOT9 [mitochondrial matrix] (R-HSA-5690069)	0.615	14
UniProt:Q69YQ0 CYTSA			0.615	16
UniProt:O95831 AIFM1			0.615	11
UniProt:P29966 MARCKS	2	p-4S-MARCKS [plasma membrane] (R-HSA-399989) MARCKS [plasma membrane] (R-HSA-399985)	0.615	14
UniProt:O60762 DPM1	4	DPM1 R92G [endoplasmic reticulum membrane] (R-HSA-4717370) DPM1 Q210Rfs4 [endoplasmic reticulum membrane] (R-HSA-4717361) DPM1 G111Lfs45 [endoplasmic reticulum membrane] (R-HSA-4717383) DPM1 [endoplasmic reticulum membrane] (R-HSA-162865)	0.615	11
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.615	10
UniProt:P53621 COPA	4	COPA [endoplasmic reticulum membrane] (R-HSA-6810953) COPA [Golgi membrane] (R-HSA-6808731) COPA [transport vesicle] (R-HSA-6808732) COPA [cytosol] (R-HSA-199978)	0.615	16
UniProt:P25398 RPS12	2	RPS12 [nucleoplasm] (R-HSA-6798715) RPS12 [cytosol] (R-HSA-72329)	0.615	18
UniProt:P29992 GNA11	1	GNA11 [plasma membrane] (R-HSA-167446)	0.615	6
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.615	15
UniProt:Q92614 MYO18A	4	MYO18A(1-1462)-FLT3(595-993) fusion [cytosol] (R-HSA-9703314) MYO18A(1-1462)-p-4Y-FLT3(595-993) fusion [cytosol] (R-HSA-9703306) MYO18A(1-1691)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606446) MYO18A(1-1691)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839006)	0.615	15
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.615	15
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.615	18
UniProt:Q9BR76 COR1B			0.615	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.615	15
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.615	18
UniProt:P67936 TPM4	3	TPM4 [cytosol] (R-HSA-390548) TPM4(2-222)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710841) TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710851)	0.615	19
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.615	13
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.615	20
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.615	15
UniProt:Q9ULV4 COR1C			0.615	16
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.615	9
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.615	19
UniProt:Q7Z406 MYH14	1	MYH14 [cytosol] (R-HSA-419176)	0.615	20
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835)	0.615	21
UniProt:P84090 ERH			0.615	14
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.615	16
UniProt:Q08554 DSC1	3	DSC1 [cornified envelope] (R-HSA-8847712) DSC1 [plasma membrane] (R-HSA-6801533) DSC1 [ficolin-1-rich granule membrane] (R-HSA-6801378)	0.615	5
UniProt:Q9UJZ1 STOML2	1	STOML2 [mitochondrial inner membrane] (R-HSA-8953739)	0.615	13
UniProt:Q5D862 FLG2	2	FLG2 [extracellular region] (R-HSA-6801543) FLG2 [tertiary granule lumen] (R-HSA-6801471)	0.615	12
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.615	8
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.615	14
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.615	19
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.615	19
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.615	20
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.615	18
UniProt:Q15293 RCN1	2	p-RCN1 [endoplasmic reticulum lumen] (R-HSA-8956989) RCN1 [endoplasmic reticulum lumen] (R-HSA-8956758)	0.615	13
UniProt:P30048 PRDX3	1	PRDX3 [mitochondrial matrix] (R-HSA-3323081)	0.615	14
UniProt:Q8WWM7 ATX2L			0.615	5
UniProt:P53396 ACLY	4	ACLY [ficolin-1-rich granule lumen] (R-HSA-6801031) ACLY [extracellular region] (R-HSA-6806218) ACLY [azurophil granule lumen] (R-HSA-6798765) ACLY [cytosol] (R-HSA-76187)	0.615	17
UniProt:P55786 NPEPPS	1	NPEPPS [cytosol] (R-HSA-983056)	0.615	17
UniProt:Q9H3U1 UN45A			0.615	17
UniProt:Q14152 EIF3A	1	EIF3A [cytosol] (R-HSA-72546)	0.615	11
UniProt:Q9UBQ5 EIF3K	1	EIF3K [cytosol] (R-HSA-72554)	0.615	11
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.615	18
UniProt:Q15233 NONO			0.615	14
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.615	15
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.615	15
UniProt:P25705 ATP5F1A	3	ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978) ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5F1A [mitochondrial matrix] (R-HSA-164575)	0.615	20
UniProt:P34897 SHMT2	2	SHMT2 [cytosol] (R-HSA-9714752) PXLP-K280-SHMT2 [mitochondrial inner membrane] (R-HSA-5694086)	0.615	10
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.615	11
UniProt:P31150 GDI1	1	GDI1 [cytosol] (R-HSA-195106)	0.615	7
UniProt:P31153 MAT2A	1	MAT2A [cytosol] (R-HSA-174363)	0.615	14
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.615	16
UniProt:P15924 DSP	4	DSP [cornified envelope] (R-HSA-8847736) DSP [ficolin-1-rich granule membrane] (R-HSA-6801396) DSP(?-?) [plasma membrane] (R-HSA-351843) DSP [plasma membrane] (R-HSA-201580)	0.615	18
UniProt:Q03252 LMNB2			0.615	6
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.615	14
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.615	15
UniProt:P55060 XPO2			0.615	15
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.615	8
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.615	10
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.615	20
UniProt:Q04760 GLO1	1	GLO1 [cytosol] (R-HSA-5694127)	0.615	16
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.615	11
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.615	14
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.615	19
UniProt:P58107 EPIPL			0.615	16
UniProt:Q9UBX3 SLC25A10	1	SLC25A10 [mitochondrial inner membrane] (R-HSA-372848)	0.615	13
UniProt:P25685 DNAJB1	3	p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241) DNAJB1 [cytosol] (R-HSA-3299666) DNAJB1 [nucleoplasm] (R-HSA-5082366)	0.615	12
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.615	14
UniProt:P17858 PFKL	4	PFKL [secretory granule lumen] (R-HSA-6800876) PFKL [extracellular region] (R-HSA-6806471) PFKL [ficolin-1-rich granule lumen] (R-HSA-6801030) PFKL [cytosol] (R-HSA-70459)	0.615	16
UniProt:P49207 RPL34	1	RPL34 [cytosol] (R-HSA-72458)	0.615	18
UniProt:O14974 PPP1R12A	4	p-S473-PPP1R12A [nucleoplasm] (R-HSA-3002801) p-T696,S852-PPP1R12A [cytosol] (R-HSA-419079) PPP1R12A [cytosol] (R-HSA-419070) p-T696-PPP1R12A [cytosol] (R-HSA-5668956)	0.615	13
UniProt:Q8WUY1 THEM6			0.615	6
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.615	8
UniProt:Q00325 S25A3			0.615	15
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.615	16
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.615	10
UniProt:P40616 ARL1	2	MyrG-ARL1 [cytosol] (R-HSA-6813896) MyrG-ARL1 [trans-Golgi network membrane] (R-HSA-6813898)	0.615	14
UniProt:Q9UKM9 RALY			0.615	10
UniProt:P06753 TPM3	3	TPM3 [cytosol] (R-HSA-390543) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848)	0.615	14
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.615	17
UniProt:Q96TA1 NIBA2			0.615	14
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.615	14
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.615	10
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.615	13
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	15
UniProt:O94832 MYO1D			0.615	19
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.615	11
UniProt:P61106 RAB14	7	GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.615	12
UniProt:Q96P70 IPO9			0.615	21
UniProt:Q9UGI8 TES			0.615	12
UniProt:P29401 TKT	1	TKT [cytosol] (R-HSA-71321)	0.615	9
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.615	13
UniProt:P18669 PGAM1	4	PGAM1 [secretory granule lumen] (R-HSA-6803293) PGAM1 [extracellular region] (R-HSA-6806482) PGAM1 [ficolin-1-rich granule lumen] (R-HSA-6803309) PGAM1 [cytosol] (R-HSA-71442)	0.615	12
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.615	21
UniProt:O14579 COPE	4	COPE [endoplasmic reticulum membrane] (R-HSA-6810959) COPE [Golgi membrane] (R-HSA-6808743) COPE [transport vesicle] (R-HSA-6808745) COPE [cytosol] (R-HSA-199969)	0.615	11
UniProt:O00165 HAX1			0.615	11
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.615	21
UniProt:Q96J02 ITCH	2	Ub-C871-ITCH [cytosol] (R-HSA-8864515) ITCH [cytosol] (R-HSA-975995)	0.615	15
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.615	11
UniProt:O00159 MYO1C	1	MYO1C [cytosol] (R-HSA-1449619)	0.615	20
UniProt:Q08209 PPP3CA	2	PPP3CA [nucleoplasm] (R-HSA-2685599) PPP3CA [cytosol] (R-HSA-201771)	0.615	10
UniProt:Q9H4M9 EHD1	1	EHD1 [endosome membrane] (R-HSA-1011616)	0.615	14
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.615	15
UniProt:Q96N67 DOCK7	1	DOCK7 [cytosol] (R-HSA-1012970)	0.615	13
UniProt:P05387 RPLP2	1	RPLP2 [cytosol] (R-HSA-72400)	0.615	16
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.615	20
UniProt:Q15181 PPA1	1	PPA1 [cytosol] (R-HSA-71725)	0.615	11
UniProt:P04080 CSTB	4	CSTB [secretory granule lumen] (R-HSA-6801394) CSTB [ficolin-1-rich granule lumen] (R-HSA-6801376) CSTB [extracellular region] (R-HSA-6801567) CSTB [tertiary granule lumen] (R-HSA-6801398)	0.615	12
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.615	10
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.615	12
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.615	12
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.615	13
UniProt:rl10_rl10l_human EBI-25396130			0.615	8
UniProt:P13807 GYS1	3	p-S-GYS1 [cytosol] (R-HSA-71570) GYS1 [cytosol] (R-HSA-71565) GYS1 R462* [cytosol] (R-HSA-3828056)	0.615	5
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.615	16
UniProt:Q9NVI7 ATD3A			0.615	10
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.615	10
UniProt:P53007 SLC25A1	1	SLC25A1 [mitochondrial inner membrane] (R-HSA-372445)	0.615	8
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.615	21
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.615	12
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.615	17
UniProt:Q5SRE5 NUP188	2	NUP188 [cytosol] (R-HSA-9634172) NUP188 [nuclear envelope] (R-HSA-157752)	0.615	13
UniProt:P46778 RPL21	1	RPL21 [cytosol] (R-HSA-72426)	0.615	16
UniProt:O95373 IPO7			0.615	13
UniProt:O43707 ACTN4	3	ACTN4 [cytosol] (R-HSA-390558) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729)	0.615	19
UniProt:Q9HAV7 GRPEL1	1	GRPEL1 [mitochondrial inner membrane] (R-HSA-1252062)	0.615	10
UniProt:P46783 RPS10	2	RPS10 [nucleoplasm] (R-HSA-6798733) RPS10 [cytosol] (R-HSA-72325)	0.615	14
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.615	14
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.615	14
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.615	14
UniProt:O75521 ECI2			0.615	18
UniProt:P18085 ARF4	1	ARF4 [cytosol] (R-HSA-5618178)	0.615	13
UniProt:Q96IZ0 PAWR			0.615	15
UniProt:Q14254 FLOT2	1	FLOT2 [plasma membrane] (R-HSA-8849895)	0.615	12
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.615	8
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.615	10
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.615	20
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.615	22
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.615	7
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.615	14
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.615	12
UniProt:Q9UBM7 DHCR7	1	DHCR7 [endoplasmic reticulum membrane] (R-HSA-196423)	0.615	8
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.615	16
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.615	20
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.615	16
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.615	13
UniProt:Q15366 PCBP2	2	PCBP2 [nucleoplasm] (R-HSA-71921) PCBP2 [cytosol] (R-HSA-983457)	0.615	18
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.615	16
UniProt:Q04837 SSBP1	1	SSBP1 [mitochondrial matrix] (R-HSA-1592217)	0.615	11
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.615	20
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.615	19
UniProt:P19105 MYL12A	2	p-S19-MYL12A [cytosol] (R-HSA-390749) MYL12A [cytosol] (R-HSA-390735)	0.615	19