Reactome | POLE4 [nucleoplasm]

POLE4 [nucleoplasm]

Stable Identifier

R-HSA-8866684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA polymerase epsilon subunit 4 ecNumber2.7.7.7/ecNumber, DPOE4_HUMAN

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Base Excision Repair (Homo sapiens)
  - Resolution of Abasic Sites (AP sites) (Homo sapiens)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
      - PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
        
        FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
- DNA Damage Bypass (Homo sapiens)
  - Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
    - PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
      - POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Termination of translesion DNA synthesis (Homo sapiens)
      - POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NR33 POLE4

Gene Names

POLE4

Chain

initiator methionine:, chain:2-117

Reference Genes

BioGPS Gene:56655 POLE4

COSMIC (genes):POLE4 POLE4

CTD Gene:56655 POLE4

dbSNP Gene:56655 POLE4

ENSEMBL:ENSG00000115350 POLE4

HGNC:18755 POLE4

KEGG:hsa:56655 POLE4

Monarch:56655 POLE4

NCBI Gene:56655 POLE4

OMIM:607269 POLE4

UCSC:Q9NR33 POLE4

Reference Transcript

RefSeq:NM_019896.3 POLE4

Other Identifiers

11722215_at

1553587_PM_a_at

1553587_a_at

16881875

225844_PM_at

225844_at

2489615

2489616

2489617

2489618

2489619

2489620

2489621

2489622

2489623

2489626

2489627

2489628

2489629

2489630

56655

63793_at

8042953

A_14_P137080

A_14_P202196

A_23_P154234

A_23_P383385

A_33_P3229177

GE56916

GE82488

GO:0003677

GO:0003824

GO:0003887

GO:0005515

GO:0005634

GO:0005654

GO:0006260

GO:0006261

GO:0008622

GO:0016740

GO:0043226

GO:0046982

GO:0071897

GO:0140097

GO:0140672

HMNXSV003008243

Hs.19980.0.S1_3p_at

Hs2.19980.1.S1_3p_s_at

ILMN_1660063

PH_hs_0027593

PH_hs_0035377

TC02000470.hg

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Homo sapiens)

Inferred To

dpb3 [nucleoplasm] (Schizosaccharomyces pombe)

Pole4 [nucleoplasm] (Mus musculus)

Pole4 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of POLE4 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of POLE4 [nucleoplasm] (Plasmodium falciparum)

POLE4 [nucleoplasm] (Bos taurus)

POLE4 [nucleoplasm] (Canis familiaris)

POLE4 [nucleoplasm] (Dictyostelium discoideum)

POLE4 [nucleoplasm] (Gallus gallus)

POLE4 [nucleoplasm] (Sus scrofa)

pole4 [nucleoplasm] (Xenopus tropicalis)

DLS1 [nucleoplasm] (Saccharomyces cerevisiae)

DPB3 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of POLE4 [nucleoplasm] (Saccharomyces cerevisiae)

PolE4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_063949.2

ENSEMBL

ENSP00000420176, ENST00000483063, ENSG00000115350

OpenTargets

ENSG00000115350

GeneCards

POLE4

HPA

ENSG00000115350-POLE4

PRO

Q9NR33

Pharos - Targets

Q9NR33

GlyGen

Q9NR33

HMDB Protein

HMDBP00956

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