misfolded CFTR is degraded by the 26S proteasome

Stable Identifier
R-HSA-8866553
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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misfolded CFTR is degraded by the 26S proteasome
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After VCP-mediated translocation to the cytosol, misfolded CFTR is degraded by the 26S proteasome (El Khouri et al, 2013).
Literature References
PubMed ID Title Journal Year
24019521 RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

El Khouri, E, Toledano, MB, Le Pavec, G, Delaunay-Moisan, A

J. Biol. Chem. 2013
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Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Danio rerio)
misfolded CFTR is degraded by the 26S proteasome (Dictyostelium discoideum)
misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)
misfolded CFTR is degraded by the 26S proteasome (Gallus gallus)
misfolded CFTR is degraded by the 26S proteasome (Mus musculus)
misfolded CFTR is degraded by the 26S proteasome (Plasmodium falciparum)
misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)
misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)
misfolded CFTR is degraded by the 26S proteasome (Xenopus tropicalis)
Authored
Rothfels, K  (2016-04-02)
Reviewed
D'Eustachio, P  (2016-04-23)
Created
Rothfels, K  (2016-04-02)
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