Reelin signalling pathway

Stable Identifier
R-HSA-8866376
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Reelin signalling pathway
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Reelin (RELN) is an extracellular, multifunctional signal glycoprotein that controls not only the positioning of neurons in the developing brain, but also their growth, maturation, and synaptic activity in the adult brain (Stranahan et al. 2013). Abnormal Reelin expression in the brain is implicated in a number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder and Alzheimer's disease (Folsom & Fatemi 2013).
Literature References
PubMed ID Title Journal Year
23352928 Reelin signaling in development, maintenance, and plasticity of neural networks

Stranahan, AM, Wosiski-Kuhn, M, Erion, JR

Ageing Res. Rev. 2013
22981949 The involvement of Reelin in neurodevelopmental disorders

Fatemi, SH, Folsom, TD

Neuropharmacology 2013
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Orthologous Events
Reelin signalling pathway (Bos taurus)
Reelin signalling pathway (Canis familiaris)
Reelin signalling pathway (Gallus gallus)
Reelin signalling pathway (Mus musculus)
Reelin signalling pathway (Rattus norvegicus)
Reelin signalling pathway (Sus scrofa)
Authored
Jassal, B  (2016-03-31)
Reviewed
D'Eustachio, P  (2016-04-05)
Created
Jassal, B  (2016-03-31)
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