Reactome | VLDL binds APOC1 and APOC4

VLDL binds APOC1 and APOC4

Stable Identifier

R-HSA-8866321

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Newly formed very low-density lipoprotein (VLDL) released from the liver can acquire lipoproteins in the circulation. Apolipoprotein C-I (APOC1) is a 6.6 kDa apolipoprotein that is synthesised mainly in the liver but also in other tissues. It is a constituent of triglyceride-rich lipoproteins (around 10% of the protein of VLDLs and 2% of HDLs) that slow the circulatory clearance of triglyceride-rich lipoproteins by a variety of mechanisms. As well as binding and inhibiting triglyceride-rich lipoprotein uptake by the very low-density lipoprotein receptor (VLDLR), it can also binds free fatty acids (FAs) in the circulation, reducing their uptake by cells (Shachter 2001, Hansen et al. 2011). A minor constituent of VLDL is apolipoprotein IV (APO4) (Kotite et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12700345	Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins Havel, RJ, Kotite, L, Zhang, LH, Yu, Z, Burlingame, AL	J. Lipid Res.	2003
11353333	Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism Shachter, NS	Curr. Opin. Lipidol.	2001
21776394	The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis Björkegren, J, Deguchi, H, Hansen, JB, Mathiesen, EB, Notø, AT, Fernández, JA	J Lipids	2011