Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pre-VLDL binds lipids to form VLDL
Stable Identifier
R-HSA-8866304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
VLDL assembly (Homo sapiens)
pre-VLDL binds lipids to form VLDL (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The assembly of very low-density lipoprotein (VLDL) occurs in two steps (Olofsson et al. 2000). In the second step, pre-VLDL in the smooth ER lumen binds the major lipids that form bona fide VLDL; triacylglycerols (TAG) (50%), phospholipids (PL) (20%), cholesterol (CHOL) (10%) and cholesteryl esters (CHEST) (5%).
Literature References
PubMed ID
Title
Journal
Year
11369260
Intracellular assembly of VLDL: two major steps in separate cell compartments
Asp, L
,
Olofsson, SO
,
Stillemark-Billton, P
Trends Cardiovasc. Med.
2000
Participants
Input
x 150
CHEST [smooth endoplasmic reticulum]
x 680
CHOL [smooth endoplasmic reticulum]
x 459
PL [smooth endoplasmic reticulum]
pre-VLDL [smooth endoplasmic reticulum]
(Homo sapiens)
x 899
TAG [smooth endoplasmic reticulum]
Output
VLDL [smooth endoplasmic reticulum]
(Homo sapiens)
Participates
as an event of
VLDL assembly (Homo sapiens)
Orthologous Events
pre-VLDL binds lipids to form VLDL (Bos taurus)
pre-VLDL binds lipids to form VLDL (Canis familiaris)
pre-VLDL binds lipids to form VLDL (Gallus gallus)
pre-VLDL binds lipids to form VLDL (Mus musculus)
pre-VLDL binds lipids to form VLDL (Rattus norvegicus)
pre-VLDL binds lipids to form VLDL (Sus scrofa)
Authored
Jassal, B (2016-03-30)
Reviewed
D'Eustachio, P (2016-04-05)
Created
Jassal, B (2016-03-30)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text