ADBRK1,2 phosphorylate AVPR2

Stable Identifier
R-HSA-8866268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AVPR2 is phosphorylated by ADBRK1 and 2 in an agonist-dependent manner as a prerequisite for beta-arrestin binding and endocytosis (Ren et al, 2005; reviewed in Gurevich and Gurevich, 2006).

Literature References
PubMed ID Title Journal Year
15671180 Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

Ren, XR, Reiter, E, Ahn, S, Kim, J, Chen, W, Lefkowitz, RJ

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-adrenergic receptor kinase activity of ADBRK1,2 [cytosol]
Physical Entity
Activity
Orthologous Events
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