ADBRK1,2 phosphorylate AVPR2

Stable Identifier
R-HSA-8866268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ADBRK1,2 phosphorylate AVPR2
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AVPR2 is phosphorylated by ADBRK1 and 2 in an agonist-dependent manner as a prerequisite for beta-arrestin binding and endocytosis (Ren et al, 2005; reviewed in Gurevich and Gurevich, 2006).
Literature References
PubMed ID Title Journal Year
15671180 Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

Chen, W, Ahn, S, Kim, J, Reiter, E, Lefkowitz, RJ, Ren, XR

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

beta-adrenergic receptor kinase activity of ADBRK1,2 [cytosol]

Physical Entity
ADBRK1,2 [cytosol] (Homo sapiens)
Activity
beta-adrenergic receptor kinase activity (GO:0047696)
Orthologous Events
ADBRK1,2 phosphorylate AVPR2 (Bos taurus)
ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)
ADBRK1,2 phosphorylate AVPR2 (Mus musculus)
ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)
ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)
ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)
Authored
Rothfels, K  (2016-05-11)
Reviewed
Antonescu, CN  (2016-05-10)
Created
Rothfels, K  (2016-03-29)
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