Reactome | SH3BP4 [cytosol]

SH3BP4 [cytosol]

Stable Identifier

R-HSA-8866227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH3 domain-binding protein 4, SH3B4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P42566 EPS15

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External Reference Information

External Reference

UniProt:Q9P0V3 SH3BP4

Gene Names

SH3BP4, BOG25, EHB10, TTP

Chain

chain:1-963

Reference Genes

BioGPS Gene:23677 SH3BP4

COSMIC (genes):SH3BP4 SH3BP4

CTD Gene:23677 SH3BP4

dbSNP Gene:23677 SH3BP4

ENSEMBL:ENSG00000130147 SH3BP4

ENSEMBL_homo_sapiens_GENE:ENSG00000130147.16 SH3BP4

HGNC:10826 SH3BP4

KEGG Gene (Homo sapiens):23677 SH3BP4

Monarch:23677 SH3BP4

NCBI Gene:23677 SH3BP4

OMIM:605611 SH3BP4

UCSC:Q9P0V3 SH3BP4

Reference Transcript

Other Identifiers

11720658_a_at

11751004_x_at

11754466_a_at

16892750

222258_PM_s_at

222258_s_at

23677

2533492

2533494

2533511

2533512

2533513

2533525

2533538

2533539

2533540

2533543

2533544

2533545

2533546

2533547

2533548

2533555

2533556

2533557

2533558

2533559

2533561

63396_at

8049435

A_14_P120051

A_23_P79259

A_33_P3273369

GE58598

GO:0005092

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005886

GO:0005905

GO:0006897

GO:0006914

GO:0008285

GO:0010508

GO:0016020

GO:0016192

GO:0023052

GO:0030136

GO:0030308

GO:0031267

GO:0031410

GO:0032007

GO:0034260

GO:0042802

GO:0043226

GO:0050790

GO:0061462

GO:0070062

GO:0071230

GO:0098772

HMNXSV003011512

Hs.17667.1.S1_3p_a_at

ILMN_1785330

PH_hs_0027587

PH_hs_0030751

TC02001426.hg

This entity regulates

Negatively

RRAGA,B exchanges GDP for GTP (Homo sapiens)

Inferred To

sh3bp4a [cytosol] (Danio rerio)

SH3BP4 [cytosol] (Bos taurus)

SH3BP4 [cytosol] (Canis familiaris)

SH3BP4 [cytosol] (Gallus gallus)

SH3BP4 [cytosol] (Sus scrofa)

sh3bp4 [cytosol] (Xenopus tropicalis)

Sh3bp4 [cytosol] (Mus musculus)

Sh3bp4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_011509194.1, XP_011509196.1, XP_011509195.1, XP_011509193.1, NP_055336.1

OpenTargets

ENSG00000130147

HPA

ENSG00000130147-SH3BP4

GeneCards

Q9P0V3

Ensembl

ENSG00000130147, ENST00000392011, ENSP00000375867, ENST00000344528, ENST00000409212, ENSP00000386862, ENSP00000340237

PRO

Q9P0V3

Pharos - Targets

Q9P0V3

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.905	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.763	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.745	6
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.736	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.731	5
UniProt:P02786 TFRC	5	TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.668	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.65	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.64	4
UniProt:P39052 Dnm2	5	DNM2 [Golgi membrane] (R-RNO-2980842) DNM2 [endocytic vesicle membrane] (R-RNO-2029000) Dnm2 [cytosol] (R-RNO-9619847) DNM2 [lysosomal membrane] (R-RNO-2980840) Dynamin-2 [plasma membrane] (R-RNO-941852)	0.611	5
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.609	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:Q8NFQ8 TOIP2			0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2
UniProt:Q8TF65 GIPC2			0.527	2
UniProt:Q9Y279 VSIG4			0.527	2
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	2
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.524	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	4
UniProt:Q9ULV3 CIZ1			0.508	2
UniProt:Q9HB21 PLEKHA1	1	PLEKHA1 [plasma membrane] (R-HSA-8870328)	0.508	2

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