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p-AVPR2 [plasma membrane]
Stable Identifier
R-HSA-8866009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Vasopressin receptor type 2, RecName: Full=Vasopressin V2 receptor; AltName: Full=AVPR V2; AltName: Full=Renal-type arginine vasopressin receptor; AltName: Full=Antidiuretic hormone receptor;
GN Name=AVPR2; Synonyms=ADHR, DIR, DIR3, V2R;
OS Homo sapiens, V2R_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
ARRB bind GPCRs (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
p-AVPR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30518 AVPR2
Gene Names
AVPR2, ADHR, DIR, DIR3, V2R
Chain
chain:1-371
Reference Genes
BioGPS Gene:554 AVPR2
COSMIC (genes):AVPR2 AVPR2
CTD Gene:554 AVPR2
dbSNP Gene:554 AVPR2
ENSEMBL:ENSG00000126895 AVPR2
ENSEMBL_homo_sapiens_GENE:ENSG00000126895.16 AVPR2
HGNC:897 AVPR2
KEGG Gene (Homo sapiens):554 AVPR2
Monarch:554 AVPR2
NCBI Gene:554 AVPR2
OMIM:300538 AVPR2
UCSC:P30518 AVPR2
Reference Transcript
RefSeq:NM_001146151.1 AVPR2
RefSeq:NM_000054.4 AVPR2
RefSeq:XM_006724828.3 AVPR2
Other Identifiers
11745688_a_at
17108213
208108_PM_s_at
208108_s_at
208111_PM_at
208111_at
3996049
3996050
3996051
3996052
3996053
3996054
3996055
3996056
3996062
554
667_at
8170794
A_14_P131078
A_23_P346800
GE57677
GO:0001992
GO:0003013
GO:0003014
GO:0003084
GO:0003092
GO:0004930
GO:0005000
GO:0005515
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0007165
GO:0007186
GO:0007188
GO:0007190
GO:0007599
GO:0008284
GO:0008285
GO:0010628
GO:0016020
GO:0021537
GO:0023052
GO:0030139
GO:0030669
GO:0031410
GO:0032870
GO:0034097
GO:0035811
GO:0038023
GO:0042277
GO:0043226
GO:0045777
GO:0045907
GO:0048471
GO:0048856
GO:0050886
GO:0060089
GO:1902533
HMNXSV003042581
ILMN_1698324
L22206_at
PH_hs_0000336
TC0X000760.hg
TC0X001930.hg
g2623239_3p_a_at
Participates
as a component of
p-AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
Other forms of this molecule
AVPR2 [clathrin-coated endocytic vesicle membrane]
AVPR2 [plasma membrane]
Inferred To
phospho-avpr2 [plasma membrane]
(Xenopus tropicalis)
phospho-si:dkey-257i7.3 [plasma membrane]
(Danio rerio)
phospho-AVPR2 [plasma membrane]
(Bos taurus)
phospho-AVPR2 [plasma membrane]
(Canis familiaris)
phospho-AVPR2 [plasma membrane]
(Sus scrofa)
phospho-Avpr2 [plasma membrane]
(Mus musculus)
phospho-Avpr2 [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_000045.1
,
NP_001139623.1
,
XP_006724891.1
ZINC - World Drugs
V2R_HUMAN
Guide to Pharmacology - Targets
368
OpenTargets
ENSG00000126895
ZINC - FDA approved
V2R_HUMAN
ZINC - Substances
V2R_HUMAN
ZINC target
P30518
ZINC - Biogenic
V2R_HUMAN
PRO
P30518
PDB
4JQI
,
8GOC
,
7BB6
,
7DFA
,
7DFB
,
7R0C
,
8JRU
,
6NI2
,
6U1N
,
8I10
,
7R0J
,
7DW9
,
7DF9
,
7DFC
,
8JRV
,
7KH0
,
7BB7
ZINC - Investigational
V2R_HUMAN
ZINC - Metabolites
V2R_HUMAN
GeneCards
P30518
HPA
ENSG00000126895-AVPR2
Ensembl
ENSP00000338072
,
ENSG00000126895
,
ENST00000646375
,
ENST00000337474
,
ENSP00000496396
,
ENST00000370049
,
ENSP00000359066
Pharos - Targets
P30518
Orphanet
15344
ZINC - Predictions - Purchasable
V2R_HUMAN
HMDB Protein
HMDBP01725
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IVJ1 SLC41A1
1
SLC41A1 [plasma membrane]
(R-HSA-442659)
0.556
3
IntAct:EBI-23343277 CCSB ORF ID
0.556
3
UniProt:P21964 COMT
2
COMT [plasma membrane]
(R-HSA-379386)
COMT [cytosol]
(R-HSA-175974)
0.556
3
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Cite Us!
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