Reactome | ZRSR2 [nucleoplasm]

ZRSR2 [nucleoplasm]

Stable Identifier

R-HSA-8865914

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, U2AFM_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96I25 RBM17

Expand all

Literature References

PubMed ID	Title	Journal	Year
21041408	The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing Shen, H, Zheng, X, Luecke, S, Green, MR	Genes Dev.	2010
25586593	Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome Madan, V, Kanojia, D, Li, J, Okamoto, R, Sato-Otsubo, A, Kohlmann, A, Sanada, M, Grossmann, V, Sundaresan, J, Shiraishi, Y, Miyano, S, Thol, F, Ganser, A, Yang, H, Haferlach, T, Ogawa, S, Koeffler, HP	Nat Commun	2015

External Reference Information

External Reference

UniProt:Q15696 ZRSR2

Gene Names

ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP

Chain

chain:1-482

Reference Genes

BioGPS Gene:8233 ZRSR2

COSMIC (genes):ZRSR2 ZRSR2

CTD Gene:8233 ZRSR2

dbSNP Gene:8233 ZRSR2

ENSEMBL:ENSG00000169249 ZRSR2

HGNC:23019 ZRSR2

KEGG:hsa:8233 ZRSR2

Monarch:8233 ZRSR2

NCBI Gene:8233 ZRSR2

OMIM:300028 ZRSR2

UCSC:Q15696 ZRSR2

Reference Transcript

RefSeq:NM_005089.4 ZRSR2

Other Identifiers

11758542_x_at

208174_3p_x_at

208174_PM_x_at

208174_x_at

213876_3p_x_at

213876_PM_x_at

213876_x_at

230413_PM_s_at

230413_s_at

2824319

2824320

2824321

2824322

2824324

35060_at

38523_f_at

3969943

3969945

3969947

3969948

3969950

3969953

3969955

3969956

3969957

3969958

3969960

3969963

3969968

3969969

3969970

3969971

3969973

3969974

3969975

3969976

3969977

3969978

3969979

3969980

3969981

3969982

3969983

8166195

8233

A_23_P85053

A_33_P3417620

D49677_at

GE57231

GO:0000245

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005689

GO:0006397

GO:0008270

GO:0008380

GO:0016071

GO:0030628

GO:0042802

GO:0046872

GO:0065003

GO:0089701

GO:1990904

HMNXSV003014576

HMNXSV003034635

Hs.171909.1.S1_3p_a_at

Hs.40368.3.A1_3p_a_at

ILMN_1773868

PH_hs_0008571

TC0X000072.hg

g13186299_3p_s_at

g4827045_3p_a_at

Participates

as a component of

as an input of

Formation of AT-AC A complex (Homo sapiens)

Inferred To

Dmel\CG3294 [nucleoplasm] (Drosophila melanogaster)

ZRSR2 [nucleoplasm] (Bos taurus)

ZRSR2 [nucleoplasm] (Canis familiaris)

ZRSR2 [nucleoplasm] (Gallus gallus)

ZRSR2 [nucleoplasm] (Sus scrofa)

zrsr2 [nucleoplasm] (Danio rerio)

zrsr2 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of ZRSR2 [nucleoplasm] (Caenorhabditis elegans)

Zrsr2 [nucleoplasm] (Mus musculus)

Zrsr2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005080.1

OpenTargets

ENSG00000169249

ENSEMBL

ENSG00000169249, ENST00000307771, ENSP00000303015

GeneCards

ZRSR2

HPA

ENSG00000169249-ZRSR2

PRO

Q15696

Pharos - Targets

Q15696

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.876	9
UniProt:Q9H190 SDCB2			0.781	7
UniProt:Q15695 U2AFL			0.742	6
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.725	7
UniProt:P49760 CLK2			0.718	8
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.688	3
UniProt:Q9Y2D8 ADIP			0.666	4
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	4
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.643	4
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	3
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q6BDI9 REP15			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q7Z7F0-4 KHDC4			0.556	3
UniProt:Q9UK58 CCNL1			0.556	3
UniProt:Q9Y383 LC7L2			0.556	3
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:Q8WVP5 TNFAIP8L1	1	TNFAIP8L1 [cytosol] (R-HSA-8874482)	0.556	3
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:Q8N8D1 PDCD7	1	PDCD7 [nucleoplasm] (R-HSA-6787851)	0.527	4
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:Q8N954 GPT11			0.527	2
UniProt:Q6PID6 TTC33			0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	4
UniProt:Q96F63 CCD97			0.527	2
UniProt:P50452 SERPINB8	1	SERPINB8 [plasma membrane] (R-HSA-2990856)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.527	2
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.527	2
UniProt:P30414 NKTR			0.527	2
UniProt:Q96LT9 RNPC3	1	RNPC3 [nucleoplasm] (R-HSA-6787844)	0.527	4
UniProt:Q9BWU0 NADAP			0.527	2
UniProt:Q6IEG0 SNRNP48	1	SNRNP48 [nucleoplasm] (R-HSA-6787849)	0.527	4
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2

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