MFSD2A transports LPC from extracellular region to plasma membrane

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R-HSA-8865637
Type
Reaction [transition]
Species
Homo sapiens
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Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A, aka NLS1) plays an essential role in blood-brain barrier (BBB) formation and function and transports LPC into the brain via a flipping motion (Nguyen et al. 2014, Guemez-Gamboa et al. 2015, Quek et al. 2016). LPCs are synthesised by the liver, circulate bound to albumin and serve as the chemical carrier for DHA uptake via MFSD2A. LPC can contain docosahexanoic acid (DHA), the most abundant omega-3 fatty acid in brain. Despite large DHA content in phospholipids, the brain does not synthesise it. MFSD2A is highly enriched in cerebral vasculature, where it is exclusively found in BBB endothelium.

Literature References
PubMed ID Title Journal Year
24828044 Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Nguyen, LN, Ma, D, Shui, G, Wong, P, Cazenave-Gassiot, A, Zhang, X, Wenk, MR, Goh, EL, Silver, DL

Nature 2014
26945070 Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a

Quek, DQ, Nguyen, LN, Fan, H, Silver, DL

J. Biol. Chem. 2016
26005868 Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

Guemez-Gamboa, A, Nguyen, LN, Yang, H, Zaki, MS, Kara, M, Ben-Omran, T, Akizu, N, Rosti, RO, Rosti, B, Scott, E, Schroth, J, Copeland, B, Vaux, KK, Cazenave-Gassiot, A, Quek, DQ, Wong, BH, Tan, BC, Wenk, MR, Gunel, M, Gabriel, S, Chi, NC, Silver, DL, Gleeson, JG

Nat. Genet. 2015
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Catalyst Activity
Title
phospholipid transporter activity of MFSD2A [plasma membrane]
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