MFSD2A transports LPC from extracellular region to plasma membrane

Stable Identifier
R-HSA-8865637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
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MFSD2A transports LPC from extracellular region to plasma membrane
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Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A, aka NLS1) plays an essential role in blood-brain barrier (BBB) formation and function and transports LPC into the brain via a flipping motion (Nguyen et al. 2014, Guemez-Gamboa et al. 2015, Quek et al. 2016). LPCs are synthesised by the liver, circulate bound to albumin and serve as the chemical carrier for DHA uptake via MFSD2A. LPC can contain docosahexanoic acid (DHA), the most abundant omega-3 fatty acid in brain. Despite large DHA content in phospholipids, the brain does not synthesise it. MFSD2A is highly enriched in cerebral vasculature, where it is exclusively found in BBB endothelium.
Literature References
PubMed ID Title Journal Year
26945070 Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a

Quek, DQ, Nguyen, LN, Fan, H, Silver, DL

J. Biol. Chem. 2016
24828044 Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Nguyen, LN, Ma, D, Shui, G, Wong, P, Cazenave-Gassiot, A, Zhang, X, Wenk, MR, Goh, EL, Silver, DL

Nature 2014
26005868 Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

Guemez-Gamboa, A, Nguyen, LN, Yang, H, Zaki, MS, Kara, M, Ben-Omran, T, Akizu, N, Rosti, RO, Rosti, B, Scott, E, Schroth, J, Copeland, B, Vaux, KK, Cazenave-Gassiot, A, Quek, DQ, Wong, BH, Tan, BC, Wenk, MR, Gunel, M, Gabriel, S, Chi, NC, Silver, DL, Gleeson, JG

Nat. Genet. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phospholipid transfer activity of MFSD2A [plasma membrane]

Physical Entity
MFSD2A [plasma membrane] (Homo sapiens)
Activity
phospholipid transfer activity (GO:0120014)
Orthologous Events
MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)
MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)
MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)
MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)
MFSD2A transports LPC from extracellular region to plasma membrane (Gallus gallus)
MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)
MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)
MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)
MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)
MFSD2A transports LPC from extracellular region to plasma membrane (Xenopus tropicalis)
Authored
Jassal, B  (2016-03-23)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-03-23)
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