CBFB binds RUNX3

Stable Identifier
R-HSA-8865454
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CBFB binds RUNX3
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CBFB binds the transcription factor RUNX3, interacting with its Runt domain, which is highly similar to Runt domains of RUNX1 and RUNX2 (Kim et al. 2013). RUNX3 is implicated in neurogenesis, thymopoiesis and stomach development (Inoue et al. 2002, Levanon et al. 2002, Levanon et al. 2003). RUNX3 and CBFB are frequently downregulated in gastric cancer (Sakakura et al. 2005).
Literature References
PubMed ID Title Journal Year
23333304 CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression

Hartley, PD, Mann, S, Gross, JD, Krogan, NJ, Kim, DY, Crosby, DC, Kwon, E

Mol. Cell 2013
Participants
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Output
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Orthologous Events
CBFB binds RUNX3 (Bos taurus)
CBFB binds RUNX3 (Caenorhabditis elegans)
CBFB binds RUNX3 (Canis familiaris)
CBFB binds RUNX3 (Drosophila melanogaster)
CBFB binds RUNX3 (Gallus gallus)
CBFB binds RUNX3 (Mus musculus)
CBFB binds RUNX3 (Rattus norvegicus)
CBFB binds RUNX3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-03-22)
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