CBFB binds the transcription factor RUNX3, interacting with its Runt domain, which is highly similar to Runt domains of RUNX1 and RUNX2 (Kim et al. 2013). RUNX3 is implicated in neurogenesis, thymopoiesis and stomach development (Inoue et al. 2002, Levanon et al. 2002, Levanon et al. 2003). RUNX3 and CBFB are frequently downregulated in gastric cancer (Sakakura et al. 2005).