OTUD7A hydrolyses K11diUb

Stable Identifier
R-HSA-8865182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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OTUD7A hydrolyses K11diUb
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OTU domain-containing protein 7A (CEZANNE2, OTUD7A ) has deubiquitinating activity that is specific for Lys11 ubiquitin linkages (Mevissen et al 2013).

Literature References
PubMed ID Title Journal Year
23827681 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

Mevissen, TE, Hospenthal, MK, Geurink, PP, Elliott, PR, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, SM, Ovaa, H, Komander, D

Cell 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of OTUD7A [cytosol]
Physical Entity
OTUD7A [cytosol]
Activity
thiol-dependent ubiquitinyl hydrolase activity (0036459)
Orthologous Events
OTUD7A hydrolyses K11diUb (Bos taurus)
OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)
OTUD7A hydrolyses K11diUb (Canis familiaris)
OTUD7A hydrolyses K11diUb (Danio rerio)
OTUD7A hydrolyses K11diUb (Gallus gallus)
OTUD7A hydrolyses K11diUb (Mus musculus)
OTUD7A hydrolyses K11diUb (Rattus norvegicus)
OTUD7A hydrolyses K11diUb (Sus scrofa)
OTUD7A hydrolyses K11diUb (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2016-03-21)