OTUD7A hydrolyses K11diUb

Stable Identifier
R-HSA-8865182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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OTUD7A hydrolyses K11diUb
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OTU domain-containing protein 7A (CEZANNE2, OTUD7A ) has deubiquitinating activity that is specific for Lys11 ubiquitin linkages (Mevissen et al 2013).

Literature References
PubMed ID Title Journal Year
23827681 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

Elliott, PR, Kulathu, Y, Geurink, PP, Hospenthal, MK, Ekkebus, R, Freund, SM, Mevissen, TE, Arnaudo, N, El Oualid, F, Ovaa, H, Wauer, T, Komander, D, Akutsu, M

Cell 2013
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of OTUD7A [cytosol]

Physical Entity
OTUD7A [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
OTUD7A hydrolyses K11diUb (Bos taurus)
OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)
OTUD7A hydrolyses K11diUb (Canis familiaris)
OTUD7A hydrolyses K11diUb (Gallus gallus)
OTUD7A hydrolyses K11diUb (Mus musculus)
OTUD7A hydrolyses K11diUb (Plasmodium falciparum)
OTUD7A hydrolyses K11diUb (Rattus norvegicus)
OTUD7A hydrolyses K11diUb (Sus scrofa)
OTUD7A hydrolyses K11diUb (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2016-03-21)
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