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TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter
Stable Identifier
R-HSA-8864690
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)
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The gene encoding KIT receptor tyrosine kinase contains two AP-2 binding sites in its promoter. AP-2 (TFAP2) transcription factor family members TFAP2A (AP-2 alpha) and TFAP2B (AP-2 beta) can bind these sites most likely as homodimers (Huang et al. 1998). The role of TFAP2B in KIT gene regulation has been studied in less detail than the role of TFAP2A.
Literature References
PubMed ID
Title
Journal
Year
9687504
Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
Huang, S
,
Bar-Eli, M
,
Luca, M
,
Jean, D
,
Tainsky, MA
EMBO J.
1998
Participants
Input
KIT Gene [nucleoplasm]
(Homo sapiens)
TFAP2A,(TFAP2B) homodimers [nucleoplasm]
(Homo sapiens)
Output
TFAP2A,(TFAP2B) homodimers:KIT gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
Authored
Orlic-Milacic, M (2016-03-14)
Reviewed
Zarelli, VE (2016-05-04)
Bogachek, MV (2016-05-17)
Dawid, IB (2016-05-04)
Weigel, RJ (2016-05-17)
Created
Orlic-Milacic, M (2016-03-16)
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