TFAP2A,TFAP2C homodimers stimulate CGA gene expression

Stable Identifier
R-HSA-8864433
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TFAP2A,TFAP2C homodimers stimulate CGA gene expression
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Homodimers of AP-2 family transcription factors TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma) directly stimulate CGA (chorionic gonadotropin alpha) transcription by binding to the CGA promoter (Johnson et al. 1997, LiCalsi et al. 2000).
Literature References
PubMed ID Title Journal Year
9182571 Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2

Johnson, W, Albanese, C, Handwerger, S, Williams, T, Pestell, RG, Jameson, JL

J. Biol. Chem. 1997
10648798 AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin

LiCalsi, C, Christophe, S, Steger, DJ, Buescher, M, Fischer, W, Mellon, PL

Nucleic Acids Res. 2000
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
TFAP2A,TFAP2C homodimers:CGA Gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A,TFAP2C homodimers [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Dawid, IB  (2016-05-04)
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-15)
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