The CGA (chorionic gonadotropin alpha) gene promoter contains several putative AP-2 transcription factor binding sites. TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma), which are both expressed in the placenta, can both bind to the CGA promoter (Johnson et al. 1997, LiCalsi et al. 2000). It has not been examined whether TFAP2A and TFAP2C bind the CGA promoter as homodimers or heterodimers and if CITED family members are involved in TFAP2A/C-mediated transactivation of CGA transcription.