TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression

Stable Identifier
R-HSA-8864395
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression
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Binding of TFAP2A (AP-2 alpha) or TFAP2C (AP-2 gamma) dimers to the promoter of the estrogen receptor ESR1 gene promotes ESR1 transcription (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998).
Literature References
PubMed ID Title Journal Year
10497269 AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs

Weigel, RJ, McPherson, LA

Nucleic Acids Res. 1999
7891714 Transcriptional regulation of estrogen receptor in breast carcinomas

deConinck, EC, Weigel, RJ, McPherson, LA

Mol. Cell. Biol. 1995
9850080 Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways

Carter, D, Glazer, PM, Williams, T, Gumbs, AA, Zhang, J, Haffty, BG, Hurst, HC, Maher, MG, Turner, BC, Kaplan, L

Cancer Res. 1998
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
TFAP2A,TFAP2C homodimers:ESR1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A,TFAP2C homodimers [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-15)
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