Reactome | TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression

TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression

Stable Identifier

R-HSA-8864395

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression

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Binding of TFAP2A (AP-2 alpha) or TFAP2C (AP-2 gamma) dimers to the promoter of the estrogen receptor ESR1 gene promotes ESR1 transcription (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
7891714	Transcriptional regulation of estrogen receptor in breast carcinomas deConinck, EC, McPherson, LA, Weigel, RJ	Mol. Cell. Biol.	1995
10497269	AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs McPherson, LA, Weigel, RJ	Nucleic Acids Res.	1999
9850080	Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways Turner, BC, Zhang, J, Gumbs, AA, Maher, MG, Kaplan, L, Carter, D, Glazer, PM, Hurst, HC, Haffty, BG, Williams, T	Cancer Res.	1998