KCTD15 binds to the transactivation domain of the TFAP2 (AP-2) family transcription factors and inhibits their transcriptional activity without affecting their protein levels, dimerization or nuclear localization. KCTD15-mediated inhibition of TFAP2 inhibits neural crest formation. KCTD15 interaction with TFAP2A was demonstrated using human and zebrafish proteins, while KCTD15 interaction with TFAP2B and TFAP2C is inferred from their ability to inhibit AP-2 reporter activity (Zarelli and Dawid 2013). Based on sequence similarity, it is assumed that TFAP2D and TFAP2E are candidate interaction partners of KCTD15.
Zarelli, VE, Dawid, IB
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