Reactome | TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP

TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP

Stable Identifier

R-HSA-8864307

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP

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Transcriptional co-factors from the CITED family interact with the helix-span-helix (HSH) domain of TFAP2 (AP-2) family of transcription factors and recruit transcription co-activators EP300 (p300) and CREBBP (CBP) to TFAP2-bound DNA elements. CITED2 shows the highest affinity for TFAP2 proteins, followed by CITED4, while CITED1 interacts with TFAP2s with a very low affinity. The interaction with CITED proteins was specifically demonstrated for TFAP2A (AP-2 alpha), TFAP2B (AP2-beta) and TFAP2C (AP-2 gamma), and is extrapolated to TFAP2D (AP2-delta) and TFAP2E (AP-2 epsilon) based on sequence similarity (Braganca et al. 2002, Braganca et al. 2003). Mouse embryos defective for CITED2 exhibit neural crest defects, cardiac malformations and adrenal agenesis, which can at least in part be attributed to defective Tfap2 transactivation (Bamforth et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11744733	Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 Eloranta, JJ, Swingler, T, Bhattacharya, S, Shioda, T, Hurst, HC, Bragança, J, Marques, FI, Jones, T	J. Biol. Chem.	2002
11694877	Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator Bamforth, SD, Bragança, J, Bhattacharya, S, Murdoch, JN, Marques, FI, Farza, H, Eloranta, JJ, Hurst, HC, Kranc, KR, Henderson, DJ	Nat. Genet.	2001
12586840	Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 Eloranta, JJ, Bhattacharya, S, Hurst, HC, Ibbitt, JC, Bragança, J, Bamforth, SD	J. Biol. Chem.	2003