AP-2 (TFAP2) transcription factors form homo- and heterodimers

Stable Identifier
R-HSA-8864278
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AP-2 (TFAP2) transcription factors form homo- and heterodimers
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AP-2 family transcription factors (TFAP2) bind palindromic DNA response elements as dimers. AP-2 family members are able to form homo- and heterodimers through the interaction of their C-terminal helix-span-helix (HSH) motifs. Both HSH motifs and centrally located basic regions are needed for DNA binding (Williams and Tjian 1991a, Williams and Tjian 1991b).
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Orthologous Events
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Rattus norvegicus)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)
AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-14)
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