AP-2 (TFAP2) transcription factors form homo- and heterodimers

Stable Identifier
R-HSA-8864278
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AP-2 family transcription factors (TFAP2) bind palindromic DNA response elements as dimers. AP-2 family members are able to form homo- and heterodimers through the interaction of their C-terminal helix-span-helix (HSH) motifs. Both HSH motifs and centrally located basic regions are needed for DNA binding (Williams and Tjian 1991a, Williams and Tjian 1991b).

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