Reactome | Ub-C91-UBE2W [nucleoplasm]

Ub-C91-UBE2W [nucleoplasm]

Stable Identifier

R-HSA-8864205

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 W ecNumber evidence="7"2.3.2.23/ecNumber, UBE2W_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C91-UBE2W [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96B02 UBE2W

Gene Names

UBE2W, UBC16

Chain

chain:1-151

Reference Genes

BioGPS Gene:55284 UBE2W

COSMIC (genes):UBE2W UBE2W

CTD Gene:55284 UBE2W

dbSNP Gene:55284 UBE2W

ENSEMBL:ENSG00000104343 UBE2W

HGNC:25616 UBE2W

KEGG Gene (Homo sapiens):55284 UBE2W

Monarch:55284 UBE2W

NCBI Gene:55284 UBE2W

OMIM:614277 UBE2W

UCSC:Q96B02 UBE2W

Reference Transcript

Other Identifiers

0002850707

11727805_a_at

11727806_s_at

11750058_a_at

1555217_at

17078330

218521_s_at

222656_at

222657_s_at

241887_at

3140765

3140766

3140767

3140768

3140769

3140770

3140771

3140772

3140773

3140774

3140775

3140776

3140777

3140781

3140783

3140784

3140788

3140792

3140804

3140808

41923_at

46903_at

55284

59735_at

60199_at

60791_at

68729_at

77467_at

8151401

A_23_P71430

A_23_P71433

GE55943

GE650636

GE852485

GO:0000166

GO:0000209

GO:0003674

GO:0004842

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006281

GO:0006464

GO:0006513

GO:0006515

GO:0006950

GO:0006974

GO:0008150

GO:0009056

GO:0016567

GO:0016740

GO:0019899

GO:0031625

GO:0034641

GO:0043161

GO:0043167

GO:0043226

GO:0061631

GO:0070979

GO:0071218

HMNXSV003006782

Hs.128841.0.A1_3p_at

Hs.21275.0.A1_3p_a_at

Hs.21275.0.A3_3p_at

Hs2.21275.2.S1_3p_at

ILMN_1717420

ILMN_1885131

ILMN_2376142

PH_hs_0024271

TC08002385.hg

TC08002587.hg

g8922821_3p_a_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

UBE2W [nucleoplasm]

UBE2W [cytosol]

Inferred To

Ube2w [nucleoplasm] (Mus musculus)

Ube2W [nucleoplasm] (Drosophila melanogaster)

ube2wb [nucleoplasm] (Danio rerio)

LOC103694506 [nucleoplasm] (Rattus norvegicus)

UBE2W [nucleoplasm] (Canis familiaris)

UBE2W [nucleoplasm] (Gallus gallus)

UBE2W [nucleoplasm] (Sus scrofa)

Homologues of Ub-C91-UBE2W [nucleoplasm] (Rattus norvegicus)

Ub-C91-UBE2W [nucleoplasm] (Rattus norvegicus)

ube2w [nucleoplasm] (Dictyostelium discoideum)

ubc-16 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 91

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001257944.1, NP_001001481.2, NP_060769.4

OpenTargets

ENSG00000104343

IntEnz

2.3.2.23

GeneCards

Q96B02

HPA

ENSG00000104343-UBE2W

Ensembl

ENSP00000499153, ENSP00000473561, ENST00000651945, ENSP00000428813, ENST00000602593, ENSG00000104343, ENST00000517608

PRO

Q96B02

Pharos - Targets

Q96B02

HMDB Protein

HMDBP09293

PDB

2A7L, 2MT6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2