Reactome | Ub-C188-UBE2Z [cytosol]

Ub-C188-UBE2Z [cytosol]

Stable Identifier

R-HSA-8864182

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 Z, UBE2Z_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA6 substrate) [cytosol] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
        
        Ub-C188-UBE2Z [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H832 UBE2Z

Gene Names

UBE2Z, HOYS7

Chain

chain:1-354

Reference Genes

BioGPS Gene:65264 UBE2Z

COSMIC (genes):UBE2Z UBE2Z

CTD Gene:65264 UBE2Z

dbSNP Gene:65264 UBE2Z

ENSEMBL:ENSG00000159202 UBE2Z

HGNC:25847 UBE2Z

KEGG:hsa:65264 UBE2Z

Monarch:65264 UBE2Z

NCBI Gene:65264 UBE2Z

OMIM:611362 UBE2Z

UCSC:Q9H832 UBE2Z

Reference Transcript

RefSeq:NM_023079.4 UBE2Z

Other Identifiers

11716650_a_at

11716651_a_at

11745884_a_at

11745885_a_at

16835497

217750_PM_s_at

217750_s_at

222395_PM_s_at

222395_s_at

236107_PM_at

236107_at

3725482

3725483

3725486

3725487

3725489

3725490

3725493

3725494

3725495

3725496

3725497

3725498

3725499

3725501

44729_at

53753_at

65264

8008139

84003_at

A_23_P83438

A_24_P339305

A_24_P378506

A_33_P3390521

GE82748

GO:0003824

GO:0004869

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0006915

GO:0012501

GO:0016567

GO:0016740

GO:0043065

GO:0043066

GO:0043226

GO:0060090

GO:0061631

GO:0098772

GO:0140096

HMNXSV003054953

Hs.168232.0.A1_3p_a_at

Hs.71158.0.A1_3p_at

ILMN_1658874

ILMN_1692168

ILMN_1743086

ILMN_1783771

PH_hs_0024096

TC17000634.hg

g12751494_3p_a_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA6 substrate) [cytosol] (Homo sapiens)

Other forms of this molecule

UBE2Z [cytosol]

Inferred To

Ub-C188-UBE2Z [cytosol] (Dictyostelium discoideum)

Ub-C188-UBE2Z [cytosol] (Gallus gallus)

ube2z [cytosol] (Xenopus tropicalis)

UBE2Z [cytosol] (Bos taurus)

UBE2Z [cytosol] (Canis familiaris)

UBE2Z [cytosol] (Sus scrofa)

Ube2z [cytosol] (Mus musculus)

Ube2z [cytosol] (Rattus norvegicus)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 188

Coordinate

188

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_075567.2

ENSEMBL

ENST00000360943, ENSP00000354201

OpenTargets

ENSG00000159202

IntEnz

2.3.2.23

HPA

ENSG00000159202-UBE2Z

PRO

Q9H832

Pharos - Targets

Q9H832

GlyGen

Q9H832

HMDB Protein

HMDBP09310

PDB

5A4P

Cite Us!