Reactome | Ub-C93-UBE2R2 [cytosol]

Ub-C93-UBE2R2 [cytosol]

Stable Identifier

R-HSA-8864180

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 R2, UB2R2_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-C93-UBE2R2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q712K3 UBE2R2

Gene Names

UBE2R2, CDC34B, UBC3B

Chain

chain:1-238

Reference Genes

BioGPS Gene:54926 UBE2R2

COSMIC (genes):UBE2R2 UBE2R2

CTD Gene:54926 UBE2R2

dbSNP Gene:54926 UBE2R2

ENSEMBL:ENSG00000107341 UBE2R2

ENSEMBL:ENSG00000107341.5 UBE2R2

HGNC:19907 UBE2R2

KEGG Gene (Homo sapiens):54926 UBE2R2

Monarch:54926 UBE2R2

NCBI Gene:54926 UBE2R2

OMIM:612506 UBE2R2

UCSC:Q712K3 UBE2R2

Reference Transcript

RefSeq:NM_017811.3 UBE2R2

Other Identifiers

11722845_s_at

11722846_at

17084403

223014_3p_at

223014_PM_at

223014_at

226954_PM_at

226954_at

3167221

3167222

3167241

3167242

3167245

3167248

3167249

3167250

3167251

3167252

3167253

3167254

3167255

3167256

3167257

46616_at

54926

56479_at

8154856

A_23_P169423

A_33_P3333820

GE55486

GE85772

GO:0000166

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005829

GO:0006511

GO:0006513

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0036211

GO:0061631

GO:0070936

GO:0140096

HMNXSV003042387

Hs.66817.0.A1_3p_at

ILMN_1675721

PH_hs_0001092

TC09000156.hg

g13436070_3p_at

g13436070_3p_s_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)

Other forms of this molecule

UBE2R2 [cytosol]

Inferred To

ube2r2 [cytosol] (Xenopus tropicalis)

Dmel\CG7656 [cytosol] (Drosophila melanogaster)

Ub-C93-UBE2R2 [cytosol] (Canis familiaris)

Ub-C93-UBE2R2 [cytosol] (Dictyostelium discoideum)

Ub-C93-UBE2R2 [cytosol] (Plasmodium falciparum)

zgc:92307 [cytosol] (Danio rerio)

Ube2r2 [cytosol] (Mus musculus)

Ube2r2 [cytosol] (Rattus norvegicus)

ubc-3 [cytosol] (Caenorhabditis elegans)

Homologues of Ub-C93-UBE2R2 [cytosol] (Plasmodium falciparum)

UBE2R2 [cytosol] (Bos taurus)

UBE2R2 [cytosol] (Gallus gallus)

UBE2R2 [cytosol] (Sus scrofa)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 93

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_060281.2

OpenTargets

ENSG00000107341

GeneCards

Q712K3

HPA

ENSG00000107341-UBE2R2

Ensembl

ENSP00000263228, ENST00000263228, ENSG00000107341

PRO

Q712K3

Pharos - Targets

Q712K3

HMDB Protein

HMDBP09289

PDB

6NYO

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3