Reactome | KIAA0319 [plasma membrane]

KIAA0319 [plasma membrane]

Stable Identifier

R-HSA-8864136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dyslexia-associated protein KIAA0319, K0319_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - AP-2 directly binds some endocytic cargo (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        KIAA0319 dimer [plasma membrane] (Homo sapiens)
        
        KIAA0319 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5VV43 KIAA0319

Gene Names

KIAA0319

Chain

signal peptide:1-20, chain:21-1072

Reference Genes

BioGPS Gene:9856 KIAA0319

COSMIC (genes):KIAA0319 KIAA0319

CTD Gene:9856 KIAA0319

dbSNP Gene:9856 KIAA0319

ENSEMBL:ENSG00000137261 KIAA0319

HGNC:21580 KIAA0319

KEGG Gene (Homo sapiens):9856 KIAA0319

Monarch:9856 KIAA0319

NCBI Gene:9856 KIAA0319

OMIM:609269 KIAA0319

UCSC:Q5VV43 KIAA0319

Reference Transcript

Other Identifiers

0000670440

0001170079

11740304_a_at

11740305_at

11740306_a_at

17016160

206017_at

2945599

2945600

2945601

2945602

2945603

2945604

2945606

2945607

2945609

2945610

2945611

2945612

2945614

2945615

2945616

2945617

2945618

2945619

2945620

2945622

2945624

2945625

2945626

2945627

2945628

2945629

2945632

2945633

2945634

2945639

2945640

2945642

2945644

39589_at

8124240

9856

A_23_P168324

A_24_P166397

GE53053

GO:0000902

GO:0001764

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0006950

GO:0007165

GO:0007275

GO:0007399

GO:0008150

GO:0010996

GO:0016020

GO:0016021

GO:0030154

GO:0030517

GO:0030665

GO:0031410

GO:0031901

GO:0033555

GO:0040007

GO:0040011

GO:0043226

GO:0043231

GO:0048692

GO:0048856

GO:0048870

GO:0060391

GO:0061024

GO:2000171

ILMN_1657497

PH_hs_0002330

TC06001326.hg

g7662053_3p_at

Participant Of

hasComponent

KIAA0319 dimer [plasma membrane]

Other forms of this molecule

KIAA0319 [clathrin-coated endocytic vesicle membrane]

Inferred To

Kiaa0319 [plasma membrane] (Mus musculus)

Homologues of KIAA0319 [plasma membrane] (Danio rerio)

Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)

KIAA0319 [plasma membrane] (Canis familiaris)

KIAA0319 [plasma membrane] (Danio rerio)

KIAA0319 [plasma membrane] (Gallus gallus)

KIAA0319 [plasma membrane] (Rattus norvegicus)

KIAA0319 [plasma membrane] (Sus scrofa)

KIAA0319 [plasma membrane] (Xenopus tropicalis)

si:ch73-215d9.1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001161846.1, NP_001161848.1, XP_016867030.1, NP_055624.2, XP_011513328.1, XP_011513327.1, NP_001161847.1, NP_001161849.1, XP_016867034.1

OpenTargets

ENSG00000137261

GeneCards

Q5VV43

HPA

ENSG00000137261-KIAA0319

Ensembl

ENSP00000439700, ENSG00000137261, ENST00000537886, ENST00000543707, ENSP00000442403, ENSP00000367459, ENST00000378214, ENSP00000401086, ENSP00000437656, ENST00000430948, ENST00000535378

PRO

Q5VV43

PDB

2E7M

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