PTPN18 binds ERBB2:EGFR heterodimers

Stable Identifier
R-HSA-8864105
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PTPN18 binds ERBB2:EGFR heterodimers
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PTPN18 protein tyrosine phosphatase (BDP1) binds ERBB2, activated in response to EGF stimulation, via PEST and catalytic domains of PTPN18 (Wang et al. 2014).
Literature References
PubMed ID Title Journal Year
25081058 The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

Yang, F, Zhang, Y, Yang, DX, Wang, HM, Ning, SL, Sun, JP, Liang, N, Li, Y, Gu, LC, Chen, YX, Gao, CJ, Pang, Q, Ma, R, Xiao, KH, Yao, W, Xu, YF, Du, YJ, Zhang, LL, Yu, X

Cell Res. 2014
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Orthologous Events
PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)
PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)
PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-03-12)
Reviewed
Ayoub, E  (2016-08-04)
Tremblay, M  (2016-08-04)
Created
Orlic-Milacic, M  (2016-03-12)
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