IKKB phosphorylates SNAP23

Stable Identifier
R-HSA-8863895
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol
ReviewStatus
5/5
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IKKB phosphorylates SNAP23
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A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).
Literature References
PubMed ID Title Journal Year
25083866 TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Nair-Gupta, P, Baccarini, A, Tung, N, Seyffer, F, Florey, O, Huang, Y, Banerjee, M, Overholtzer, M, Roche, PA, Tampé, R, Brown, BD, Amsen, D, Whiteheart, SW, Blander, JM

Cell 2014
18692471 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

Suzuki, K, Verma, IM

Cell 2008
23613522 IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Karim, ZA, Zhang, J, Banerjee, M, Chicka, MC, Al Hawas, R, Hamilton, TR, Roche, PA, Whiteheart, SW

Blood 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CHUK:IKBKB:IKBKG [cytosol]

Physical Entity
CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Positively by
Regulator
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
Authored
Garapati, P V  (2016-03-10)
Reviewed
Bergeron, JJ  (2016-05-16)
Created
Garapati, P V  (2016-03-10)
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