IKKB phosphorylates SNAP23

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).

Literature References
PubMed ID Title Journal Year
25083866 TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Tampé, R, Whiteheart, SW, Florey, O, Blander, JM, Huang, Y, Baccarini, A, Amsen, D, Overholtzer, M, Brown, BD, Seyffer, F, Tung, N, Nair-Gupta, P, Roche, PA, Banerjee, M

Cell 2014
18692471 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

Verma, IM, Suzuki, K

Cell 2008
23613522 IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Karim, ZA, Zhang, J, Al Hawas, R, Whiteheart, SW, Chicka, MC, Roche, PA, Hamilton, TR, Banerjee, M

Blood 2013
Catalyst Activity

protein serine/threonine kinase activity of CHUK:IKBKB:IKBKG [cytosol]

This event is regulated