IKKB phosphorylates SNAP23

Stable Identifier
R-HSA-8863895
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol
ReviewStatus
5/5
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IKKB phosphorylates SNAP23
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A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).
Literature References
PubMed ID Title Journal Year
25083866 TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Tampé, R, Whiteheart, SW, Florey, O, Blander, JM, Huang, Y, Baccarini, A, Amsen, D, Overholtzer, M, Brown, BD, Seyffer, F, Tung, N, Nair-Gupta, P, Roche, PA, Banerjee, M

Cell 2014
18692471 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

Verma, IM, Suzuki, K

Cell 2008
23613522 IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Karim, ZA, Zhang, J, Al Hawas, R, Whiteheart, SW, Chicka, MC, Roche, PA, Hamilton, TR, Banerjee, M

Blood 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CHUK:IKBKB:IKBKG [cytosol]

Physical Entity
CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Positively by
Regulator
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
Authored
Garapati, P V  (2016-03-10)
Reviewed
Bergeron, JJ  (2016-05-16)
Created
Garapati, P V  (2016-03-10)
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