Reactome | CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-8863866

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

calreticulin

Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R

Expand all

External Reference Information

External Reference

UniProt:P27797 CALR

Gene Names

CALR, CRTC

Chain

signal peptide:1-17, chain:18-417

Reference Genes

BioGPS Gene:811 CALR

COSMIC (genes):CALR CALR

CTD Gene:811 CALR

dbSNP Gene:811 CALR

ENSEMBL:ENSG00000179218 CALR

ENSEMBL_homo_sapiens_GENE:ENSG00000179218.15 CALR

HGNC:1455 CALR

KEGG Gene (Homo sapiens):811 CALR

Monarch:811 CALR

NCBI Gene:811 CALR

OMIM:109091 CALR

Reference Transcript

RefSeq:NM_004343.3 CALR

Other Identifiers

11715374_a_at

11715375_x_at

16858774

1752_at

200935_PM_at

200935_at

212953_PM_x_at

212953_x_at

214315_PM_x_at

214315_x_at

32543_at

3822050

3822051

3822053

3822054

3822055

3822056

3822057

3822058

3822059

3822060

3822065

3822066

3822067

3822068

3822069

3822070

3822071

3822072

3822073

8026106

811

A_14_P107778

A_23_P67288

A_33_P3292854

GE79860

GO:0000122

GO:0001669

GO:0001849

GO:0002376

GO:0002502

GO:0003677

GO:0003723

GO:0003729

GO:0005049

GO:0005178

GO:0005506

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005829

GO:0005840

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006457

GO:0006611

GO:0006874

GO:0006886

GO:0006913

GO:0007010

GO:0007155

GO:0007283

GO:0008270

GO:0008284

GO:0009410

GO:0009897

GO:0009986

GO:0010033

GO:0010595

GO:0010628

GO:0012501

GO:0012505

GO:0016020

GO:0016192

GO:0016529

GO:0017148

GO:0022414

GO:0022417

GO:0023052

GO:0030154

GO:0030163

GO:0030246

GO:0030312

GO:0030433

GO:0030670

GO:0030866

GO:0031012

GO:0031410

GO:0031625

GO:0032355

GO:0032991

GO:0033018

GO:0033116

GO:0033144

GO:0033574

GO:0034504

GO:0034975

GO:0040020

GO:0042277

GO:0042562

GO:0042824

GO:0042921

GO:0042981

GO:0043226

GO:0043231

GO:0044183

GO:0044194

GO:0044322

GO:0045665

GO:0045787

GO:0045892

GO:0046872

GO:0048387

GO:0048471

GO:0048856

GO:0048870

GO:0050681

GO:0050766

GO:0050821

GO:0051082

GO:0051087

GO:0051208

GO:0051604

GO:0055007

GO:0055065

GO:0060473

GO:0062023

GO:0065003

GO:0070062

GO:0071257

GO:0071285

GO:0071310

GO:0071682

GO:0090398

GO:0098553

GO:0098586

GO:0140013

GO:0140104

GO:0140313

GO:1900026

GO:1901164

GO:1901224

GO:1903416

GO:2000510

HMNXSV003044478

Hs.16488.2.A1_3p_x_at

Hs.16488.3.A1_3p_x_at

ILMN_1736256

M84739_at

PH_hs_0017137

TC19000232.hg

g5921996_3p_a_at

Participates

as an output of

Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)

as an input of

SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)

as a component of

CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

CALR [lumenal side of endoplasmic reticulum membrane]

CALR [extracellular region]

CALR [endocytic vesicle lumen]

CALR [endoplasmic reticulum lumen]

CALR [phagocytic vesicle membrane]

Inferred To

calr3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

calr [endoplasmic reticulum-Golgi intermediate compartment membrane] (Xenopus tropicalis)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Cross References

RefSeq

NP_004334.1

OpenTargets

ENSG00000179218

GeneCards

P27797

HPA

ENSG00000179218-CALR

Ensembl

ENSG00000179218, ENSP00000466037, ENST00000316448, ENSP00000320866, ENST00000586967

PRO

P27797

Pharos - Targets

P27797

Orphanet

22642

HMDB Protein

HMDBP07533

PDB

5LK5, 3POS, 3POW, 8TZO, 3DOW, 5V90, 7QPD, 8TZR, 6ENY, 2CLR

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.737	5
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.71	4
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.659	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.594	5
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.589	2
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:Q68CL5-3 TPGS2			0.556	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q9NX07 TSAP1			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
IntAct:EBI-25833913 CCSB			0.556	3
UniProt:Q3SY56 SP6			0.556	3
IntAct:EBI-25831691 CCSB			0.556	3
UniProt:Q96E17 RAB3C	2	GGC-RAB3C [cytosol] (R-HSA-8874012) RAB3C [cytosol] (R-HSA-8873684)	0.556	3
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q7Z780 Q7Z780			0.556	3
UniProt:Q96GK7 FAH2A			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:Q96L03 SPT17			0.556	3
UniProt:F6Y2X3 F6Y2X3			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q8N1W1-4 ARHGEF28			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:O15499 GSC2			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P14060 HSD3B1	1	HSD3B1 [endoplasmic reticulum membrane] (R-HSA-192072)	0.556	3
UniProt:P79483 HLA-DRB3	9	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130513) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130432) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane] (R-HSA-2214381) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane] (R-HSA-2130452) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane] (R-HSA-2130559) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130515) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane] (R-HSA-2130377) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (R-HSA-2130676) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane] (R-HSA-197577)	0.556	3
UniProt:Q6P4D5-2 PABIR3			0.556	3
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:O75317 USP12	1	USP12 [nucleoplasm] (R-HSA-5696907)	0.556	3
IntAct:EBI-25834143 CCSB			0.556	3
IntAct:EBI-25833532 RZPDO839F06154			0.556	3
UniProt:O75874 IDH1	10	IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546)	0.556	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:Q96EY8 MMAB	4	MMAB E193K [mitochondrial matrix] (R-HSA-3322150) MMAB R191W [mitochondrial matrix] (R-HSA-3322112) MMAB R186W [mitochondrial matrix] (R-HSA-3322128) MMAB [mitochondrial matrix] (R-HSA-2980970)	0.556	3
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.556	3
UniProt:A0JP07 A0JP07			0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.556	3
UniProt:O00214-2 LGALS8			0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q9Y3Y4 PYGO1	1	PYGO1 [nucleoplasm] (R-HSA-201705)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:O14829 PPEF1	1	PPEF1 [cytosol] (R-HSA-2632517)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q8NCF5-2 NFATC2IP			0.556	3
UniProt:P50749 RASF2			0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.556	3
IntAct:EBI-25833762 CCSB			0.556	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q8IY82 DRC7			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:Q53T94 TAF1B	2	TAF1B [nucleoplasm] (R-HSA-73691) Ac-TAF1B [nucleoplasm] (R-HSA-5138530)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [azurophil granule membrane] (R-HSA-6804972) RAP1B [plasma membrane] (R-HSA-377590)	0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.544	6
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:Q6FHJ7 SFRP4			0.527	2
UniProt:P12644 BMP4	4	BMP4 [extracellular region] (R-HSA-8858573) BMP4 [endoplasmic reticulum lumen] (R-HSA-8956775) p-BMP4 [endoplasmic reticulum lumen] (R-HSA-8956944) BMP4(20-408) [extracellular region] (R-HSA-2396280)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.508	2
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.499	2
UniProt:P29991-PRO_0000037946			0.488	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	4

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