STON2 is neddylated

Stable Identifier
R-HSA-8863727
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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STON2 is post-translationally neddylated by an unknown enzyme. Neddylation appears to contribute to STON2 destabilization, possibly by promoting its subsequent ubiquitination and degradation. Decreased STON2 protein levels are associated with increased plasma membrane levels of SYT1, reflecting a defect in its STON2-mediated recapture through endocytosis (Granata et al, 2011).

Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Koo, SJ, Haucke, V, Schiavo, G, Warner, TT

EMBO J. 2011
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