COP9 and TOR1 deneddylate STON2

Stable Identifier
R-HSA-8863723
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
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COP9 and TOR1 deneddylate STON2
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Deneddylation of STON2 by TOR1A and the COP9 signalosome stabilize the protein, allowing it to function in the endocytosis of cargo such as the SYT proteins (Granata et al, 2011).

Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Warner, TT, Schiavo, G, Haucke, V, Koo, SJ

EMBO J. 2011
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Output
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as an event of
Catalyst Activity

NEDD8-specific protease activity of NEDD8-STONs:TOR1 hexamer:COP9 [cytosol]

Physical Entity
NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] (Homo sapiens)
Activity
NEDD8-specific protease activity (GO:0019784)
Orthologous Events
COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)
COP9 and TOR1 deneddylate STON2 (Canis familiaris)
COP9 and TOR1 deneddylate STON2 (Danio rerio)
COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)
COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)
COP9 and TOR1 deneddylate STON2 (Gallus gallus)
COP9 and TOR1 deneddylate STON2 (Mus musculus)
COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)
COP9 and TOR1 deneddylate STON2 (Sus scrofa)
COP9 and TOR1 deneddylate STON2 (Xenopus tropicalis)
Authored
Rothfels, K  (2016-05-10)
Reviewed
Antonescu, CN  (2016-05-10)
Created
Rothfels, K  (2016-03-09)
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